NF-κB-mediated inflammation is the major pathology in chronic kidney diseases, including
HIV-associated nephropathy (HIVAN) that ultimately progresses to end stage renal disease. …

As a master transcription factor in cellular responses to external stress, tumor suppressor p53
is tightly regulated. Excessive p53 activity during myocardial ischemia causes irreversible …

Viruses are obligate parasites and thus require the machinery of the host cell to replicate.
Inhibition of host factors co-opted during active infection is a strategy hosts use to suppress …

RNA viruses are a major human health threat. The life cycles of many highly pathogenic RNA
viruses like influenza A virus (IAV) and Lassa virus depends on host mRNA, because viral …

Histone acetyltransferase 1 is the founding member of the histone acetyltransferase superfamily
and catalyzes lysine acetylation of newly synthesized histone H4. Here we report a 1.9-…

Viral infection perturbs host cells and can be used to uncover regulatory mechanisms
controlling cellular responses and susceptibility to infections. Using cell biological, biochemical, …

The human helicase senataxin (SETX) has been linked to the neurodegenerative diseases
amyotrophic lateral sclerosis (ALS4) and ataxia with oculomotor apraxia (AOA2). Here we …

The nuclear RNA exosome is an essential multi-subunit complex that controls RNA homeostasis.
Congenital mutations in RNA exosome genes are associated with neurodegenerative …

Viruses are obligate parasites as they require the machinery of the host cell to replicate.
Inhibition of host factors co-opted during active infection is a strategy to suppress viral replication …

Influenza A virus (IAV) is a threat to mankind because it generates yearly epidemics and
poorly predictable sporadic pandemics with catastrophic potential. IAV has a small RNA …