Embryonic stem (ES) cells form spontaneous aggregates during differentiation, and cell–cell
communication in the aggregates plays an important role in differentiation. The …

Background Liver disease contributes significantly to global disease burden and is associated
with rising incidence and escalating costs. It is likely that innovative approaches, arising …

The reshaping of the world's aging population has created an urgent need for therapies for
chronic diseases. Regenerative medicine offers a ray of hope, and its complex solutions …

One of the major hurdles of cellular therapies for the treatment of liver failure is the low
availability of functional human hepatocytes. While embryonic stem (ES) cells represent a …

The field of organoid engineering promises to revolutionize medicine with wide‐ranging
applications of scientific, engineering, and clinical interest, including precision and personalized …

SMAD pathways govern epithelial proliferation, and transforming growth factor β (TGF-β and
BMP signaling through SMAD members has distinct effects on mammary development and …

We have fabricated miniature implantable fluorescence sensors for continuous
fluorescence sensing applications in living subjects. These monolithically integrated GaAs-based …

This paper introduces a readout circuit designed to interface with the fluorescence sensor
presented in O'Sullivan et al., 2010., a monolithically integrated GaAs detector and vertical-…

Embryonic stem cell-derived endoderm is critical for the development of cellular therapies for
the treatment of disease such as diabetes, liver cirrhosis, or pulmonary emphysema. Here, …

Three-dimensional (3D) collective cell migration (CCM) is critical for improving liver cell
therapies, eliciting mechanisms of liver disease, and modeling human liver development and …