Consensus guidelines for the detection of immunogenic cell death
…, J Galon, A Garg, F Ghiringhelli, NA Giese… - …, 2014 - Taylor & Francis
Apoptotic cells have long been considered as intrinsically tolerogenic or unable to elicit
immune responses specific for dead cell-associated antigens. However, multiple stimuli can …
immune responses specific for dead cell-associated antigens. However, multiple stimuli can …
[HTML][HTML] Immunodeficiency and chronic myelogenous leukemia-like syndrome in mice with a targeted mutation of the ICSBP gene
T Holtschke, J Löhler, Y Kanno, T Fehr, N Giese… - Cell, 1996 - cell.com
Interferon consensus sequence binding protein (ICSBP) is a transcription factor of the
interferon (IFN) regulatory factor (IRF) family. Mice with a null mutation of ICSBP exhibit two …
interferon (IFN) regulatory factor (IRF) family. Mice with a null mutation of ICSBP exhibit two …
Combined evaluation of a panel of protein and miRNA serum‐exosome biomarkers for pancreatic cancer diagnosis increases sensitivity and specificity
…, S Rana, W Gross, M Müller, NA Giese… - … journal of cancer, 2015 - Wiley Online Library
Late diagnosis contributes to pancreatic cancer (PaCa) dismal prognosis, urging for reliable,
early detection. Serum‐exosome protein and/or miRNA markers might be suitable …
early detection. Serum‐exosome protein and/or miRNA markers might be suitable …
The activated stroma index is a novel and independent prognostic marker in pancreatic ductal adenocarcinoma
…, C Reiser–Erkan, I Abiatari, A Kolb, NA Giese… - Clinical …, 2008 - Elsevier
BACKGROUND AND AIMS: Pancreatic ductal adenocarcinoma (PDAC) is a highly desmoplastic
tumor with an innate resistance to therapy. Pancreatic stellate cells (PSCs) produce this …
tumor with an innate resistance to therapy. Pancreatic stellate cells (PSCs) produce this …
Pancreatic neuropathy and neuropathic pain—a comprehensive pathomorphological study of 546 cases
…, U Hinz, MW Müller, T Giese, MW Büchler, NA Giese… - Gastroenterology, 2009 - Elsevier
BACKGROUND & AIMS: Chronic pancreatitis (CP) and pancreatic adenocarcinoma (PCa)
are characterized by intrapancreatic neural alterations and pain. Our aims were to: (a) …
are characterized by intrapancreatic neural alterations and pain. Our aims were to: (a) …
Periostin creates a tumor-supportive microenvironment in the pancreas by sustaining fibrogenic stellate cell activity
…, T Mitkus, I Esposito, T Giese, MW Büchler, NA Giese… - Gastroenterology, 2007 - Elsevier
Background & Aims: Pancreatic cancer creates desmoplasia by stimulating stellate cells (PSCs),
thereby influencing tumor aggressiveness. The aim of this study was to analyze the …
thereby influencing tumor aggressiveness. The aim of this study was to analyze the …
Toward the blood-borne miRNome of human diseases
In a multicenter study, we determined the expression profiles of 863 microRNAs by array
analysis of 454 blood samples from human individuals with different cancers or noncancer …
analysis of 454 blood samples from human individuals with different cancers or noncancer …
Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer
…, E Costello, J Elena, N Funel, JM Gaziano, NA Giese… - Nature …, 2014 - nature.com
We performed a multistage genome-wide association study including 7,683 individuals with
pancreatic cancer and 14,397 controls of European descent. Four new loci reached genome…
pancreatic cancer and 14,397 controls of European descent. Four new loci reached genome…
Inhibition of heme oxygenase-1 increases responsiveness of pancreatic cancer cells to anticancer treatment
…, Z Dambrauskas, A Gulbinas, T Giese, N Giese… - Clinical cancer …, 2005 - AACR
Heme oxygenase-1 (HO-1) is believed to represent a key enzyme for the protection of cells
against “stress.” Its overexpression in different types of human cancers supports the notion …
against “stress.” Its overexpression in different types of human cancers supports the notion …
Radiotherapy orchestrates natural killer cell dependent antitumor immune responses through CXCL8
…, M Miller, RL Perez, F Bestvater, NA Giese… - Science …, 2022 - science.org
Radiotherapy is a mainstay cancer therapy whose antitumor effects partially depend on T
cell responses. However, the role of Natural Killer (NK) cells in radiotherapy remains unclear. …
cell responses. However, the role of Natural Killer (NK) cells in radiotherapy remains unclear. …