Pyroptosis is rapidly emerging as a mechanism of anti-microbial host defense, and of
extracellular release of the inflammasome-dependent cytokines interleukin (IL)-1β and IL-18, …

Familial Mediterranean fever (FMF) is the most common monogenic autoinflammatory disease
worldwide. It is caused by mutations in the inflammasome adaptor Pyrin, but how FMF …

The caspase activation and recruitment domain (CARD)-based inflammasome sensors
NLRP1b and NLRC4 induce caspase-1-dependent pyroptosis independent of the …

Inflammasomes assemble in the cytosol of myeloid and epithelial cells on sensing of cellular
stress and pathogen-associated molecular patterns and serve as scaffolds for recruitment …

The mechanisms linking systemic infection to hyperinflammation and immune dysfunction in
sepsis are poorly understood. Extracellular histones promote sepsis pathology, but their …

Inflammasomes are multi-protein platforms that are organized in the cytosol to cope with
pathogens and cellular stress. The pattern recognition receptors NLRP1, NLRP3, NLRC4, AIM2 …

The factors that influence survival during severe infection are unclear. Extracellular chromatin
drives pathology, but the mechanisms enabling its accumulation remain elusive. Here, we …

The present manuscript describes the synthesis of two novel 2,1,3-benzothiadiazole (BTD)
derivatives containing an excited state intramolecular proton transfer (ESIPT) site. …

Activating germline mutations in the human inflammasome sensor NLRP1 causes palmoplantar
dyskeratosis and susceptibility to Mendelian autoinflammatory diseases. Recent studies …

The mechanisms regulating immune dysfunction during sepsis are poorly understood. Here,
we show that neutrophil-derived myeloperoxidase delays the onset of immune dysfunction …