Homeo domain-containing proteins mediate many transcriptional processes in eukaryotes.
Because nearly all animal homeo proteins are believed to bind to short, highly related DNA …

The early Drosophila embryo is an ideal model to understand the transcriptional regulation
of well-defined patterns of gene expression in a developing organism [1]. In this system, …

Several fundamental concepts of developmental biology have emerged from studies on the
early development of the Drosophila melanogaster embryo. In the late 1980s, studies on …

Nuclear pore complexes (NPCs) are multisubunit protein entities embedded into the
nuclear envelope (NE). Here, we examine the in vivo dynamics of the essential Drosophila …

The Bicoid (Bcd) morphogen is essential for pattern formation in fruit flies. It forms an
exponential concentration gradient along the embryo AP axis and turns on cascades of target …

Background: The activity of the Bicoid (Bcd) transcription factor is a useful example of how
quantitative information contained in a smooth morphogen gradient is transformed into …

It is widely accepted that morphogenetic gradients determine cell identity by concentration-dependent
activation of target genes. How precise is each step in the gene expression …

Transmission of active transcriptional states from mother to daughter cells has the potential
to foster precision in the gene expression programs underlying development. Such …

The simultaneous expression of the hunchback gene in the numerous nuclei of the developing
fly embryo gives us a unique opportunity to study how transcription is regulated in living …

Fly development amazes us by the precision and reproducibility of gene expression, especially
since the initial expression patterns are established during very short nuclear cycles. …