We have isolated STN1, an essential Saccharomyces cerevisiae gene, as a suppressor of
the cdc13-1 mutation. A synthetic lethal interaction between a temperature-sensitive mutant …

In Saccharomyces cerevisiae, Cdc13 has been proposed to mediate telomerase recruitment
at telomere ends. Stn1, which associates with Cdc13 by the two‐hybrid interaction, has …

We have studied the patterns of expression of four B-type cyclins (Clbs), Clb1, Clb2, Clb3,
and Clb4, and their ability to activate p34 cdc28 during the mitotic and meiotic cell cycles of …

Cdc13 performs an essential function in telomere end protection in budding yeast. Here, we
analyze the consequences on telomere dynamics of cdc13‐induced telomeric DNA damage …

The Saccharomyces cerevisiae CDC13 protein binds single-strand telomeric DNA. Here we
report the isolation of new mutant alleles of CDC13 that confer either abnormal telomere …

Mutations in ATRX (alpha thalassemia/mental retardation syndrome X-linked), a chromatin-remodeling
protein, are associated with the telomerase-independent ALT (alternative …

Telomeres, the ends of linear chromosomes, contain repeated TG-rich sequences which, in
dividing cells, must be constantly replenished in order to avoid chromosome erosion and, …

Human malignant gliomas exhibit acquisition of either one of two telomere maintenance
mechanisms, resulting from either reactivation of telomerase expression or activation of an …

Background information. In budding yeast, the loss of either telomere sequences (in
telomerase‐negative cells) or telomere capping (in mutants of two telomere end‐protection proteins, …

All tumors have in common to reactivate a telomere maintenance mechanism to allow for
unlimited proliferation. On the other hand, genetic instability found in some tumors can result …