Role of Ser-652 and Lys-692 in the protease activity of infectious bursal disease virus VP4 and identification of its substrate cleavage sites
N Lejal, B Da Costa, JC Huet… - Journal of General …, 2000 - microbiologyresearch.org
The polyprotein of infectious bursal disease virus (IBDV), an avian birnavirus, is processed
by the viral protease, VP4. Previous data obtained on the VP4 of infectious pancreatic …
by the viral protease, VP4. Previous data obtained on the VP4 of infectious pancreatic …
Structure-based discovery of the novel antiviral properties of naproxen against the nucleoprotein of influenza A virus
N Lejal, B Tarus, E Bouguyon… - Antimicrobial agents …, 2013 - Am Soc Microbiol
The nucleoprotein (NP) binds the viral RNA genome and associates with the polymerase in
a ribonucleoprotein complex (RNP) required for transcription and replication of influenza A …
a ribonucleoprotein complex (RNP) required for transcription and replication of influenza A …
Active residues and viral substrate cleavage sites of the protease of the birnavirus infectious pancreatic necrosis virus
S Petit, N Lejal, JC Huet, B Delmas - Journal of Virology, 2000 - Am Soc Microbiol
The polyprotein of infectious pancreatic necrosis virus (IPNV), a birnavirus, is processed by
the viral protease VP4 (also named NS) to generate three polypeptides: pVP2, VP4, and VP3…
the viral protease VP4 (also named NS) to generate three polypeptides: pVP2, VP4, and VP3…
From naproxen repurposing to naproxen analogues and their antiviral activity against influenza A virus
S Dilly, A Fotso Fotso, N Lejal, G Zedda… - Journal of Medicinal …, 2018 - ACS Publications
The nucleoprotein (NP) of influenza A virus (IAV) required for IAV replication is a promising
target for new antivirals. We previously identified by in silico screening naproxen being a …
target for new antivirals. We previously identified by in silico screening naproxen being a …
Oligomerization paths of the nucleoprotein of influenza A virus
…, L Duchemin, LF Estrozi, C Bourdieu, N Lejal… - Biochimie, 2012 - Elsevier
The influenza viruses contain a segmented, negative strand RNA genome. Each RNA
segment is covered by multiple copies of the nucleoprotein (NP) and is associated with the …
segment is covered by multiple copies of the nucleoprotein (NP) and is associated with the …
Exploring the impact of Mg-doped ZnO nanoparticles on a model soil microorganism Bacillus subtilis
S Auger, C Henry, C Péchaux, N Lejal, V Zanet… - Ecotoxicology and …, 2019 - Elsevier
The environmental contamination of soil by metal oxide nanomaterials is a growing global
concern because of their potential toxicity. We investigated the effects of Mg doped ZnO (Mg-…
concern because of their potential toxicity. We investigated the effects of Mg doped ZnO (Mg-…
[HTML][HTML] Exploring multiple effects of Zn0.15Mg0.85O nanoparticles on Bacillus subtilis and macrophages
The increasing number of multidrug resistant bacteria raises a serious public-health concern,
which is exacerbated by the lack of new antibiotics. Metal oxide nanoparticles are already …
which is exacerbated by the lack of new antibiotics. Metal oxide nanoparticles are already …
Immunosuppressive HLA-G molecule is upregulated in alveolar epithelial cells after influenza A virus infection
…, C Menier, Y Mandouri, M Keffous, N Lejal… - Human immunology, 2009 - Elsevier
Influenza virus type A (IAV) infections constitute an important economic burden and raise
health-care problems. Host defense mechanisms usually clear IAV infections after a few days …
health-care problems. Host defense mechanisms usually clear IAV infections after a few days …
[HTML][HTML] Biosynthetic proteins targeting the SARS-CoV-2 spike as anti-virals
S Thébault, N Lejal, A Dogliani, A Donchet… - PLoS …, 2022 - journals.plos.org
The binding of the SARS-CoV-2 spike to angiotensin-converting enzyme 2 (ACE2) promotes
virus entry into the cell. Targeting this interaction represents a promising strategy to …
virus entry into the cell. Targeting this interaction represents a promising strategy to …
[HTML][HTML] Genome and polypeptides characterization of Tellina virus 1 reveals a fifth genetic cluster in the Birnaviridae family
…, M Galloux, C Henry, C Torhy, P Boudinot, N Lejal… - Virology, 2008 - Elsevier
We characterized tellina virus 1 (TV-1), a birnavirus isolated from the marine bivalve mollusk
Tellina tenuis. Genome sequence analysis established that TV-1 is representative of a viral …
Tellina tenuis. Genome sequence analysis established that TV-1 is representative of a viral …