[HTML][HTML] GLP-1 mediates antiapoptotic effect by phosphorylating Bad through a β-arrestin 1-mediated ERK1/2 activation in pancreatic β-cells
J Quoyer, C Longuet, C Broca, N Linck, S Costes… - Journal of Biological …, 2010 - ASBMB
Strategies based on activating GLP-1 receptor (GLP-1R) are intensively developed for the
treatment of type 2 diabetes. The exhaustive knowledge of the signaling pathways linked to …
treatment of type 2 diabetes. The exhaustive knowledge of the signaling pathways linked to …
Extracts enriched in different polyphenolic families normalize increased cardiac NADPH oxidase expression while having differential effects on insulin resistance …
…, A Bornet, S Delbosc, JP Cristol, N Linck… - Journal of agricultural …, 2005 - ACS Publications
Insulin resistance and oxidative stress act synergistically in the development of cardiovascular
complications. The present study compared the efficacy of three polyphenolic extracts in …
complications. The present study compared the efficacy of three polyphenolic extracts in …
[HTML][HTML] Sensory neuronal P2RX4 receptors controls BDNF signaling in inflammatory pain
S Lalisse, J Hua, M Lenoir, N Linck, F Rassendren… - Scientific reports, 2018 - nature.com
Chronic inflammatory and neuropathic pains are major public health concerns. Potential
therapeutic targets include the ATP-gated purinergic receptors (P2RX) that contribute to these …
therapeutic targets include the ATP-gated purinergic receptors (P2RX) that contribute to these …
[HTML][HTML] Comparative analysis of transcriptome remodeling in plaque-associated and plaque-distant microglia during amyloid-β pathology progression in mice
…, C Meersseman, M Pastore, V Garcia, N Linck… - Journal of …, 2022 - Springer
Background Research in recent years firmly established that microglial cells play an
important role in the pathogenesis of Alzheimer's disease (AD). In parallel, a series of studies …
important role in the pathogenesis of Alzheimer's disease (AD). In parallel, a series of studies …
β-Arrestin2 plays a key role in the modulation of the pancreatic beta cell mass in mice
MA Ravier, M Leduc, J Richard, N Linck, A Varrault… - Diabetologia, 2014 - Springer
Aims/hypothesis Beta cell failure due to progressive secretory dysfunction and limited
expansion of beta cell mass is a key feature of type 2 diabetes. Beta cell function and mass are …
expansion of beta cell mass is a key feature of type 2 diabetes. Beta cell function and mass are …
Red wine polyphenols alone or in association with ethanol prevent hypertension, cardiac hypertrophy, and production of reactive oxygen species in the insulin …
…, C Araiz, S Delbosc, JP Cristol, N Linck… - Journal of Agricultural …, 2004 - ACS Publications
The effects of a red wine polyphenolic extract (RWPE), ethanol, or both combined were
evaluated in insulin resistant rats. Rats were fed for 6 weeks with fructose (60%)-enriched food …
evaluated in insulin resistant rats. Rats were fed for 6 weeks with fructose (60%)-enriched food …
Emerging technologies to study glial cells
Abstract Development, physiological functions, and pathologies of the brain depend on tight
interactions between neurons and different types of glial cells, such as astrocytes, microglia, …
interactions between neurons and different types of glial cells, such as astrocytes, microglia, …
[HTML][HTML] Procedures for culturing and genetically manipulating murine hippocampal postnatal neurons
E Moutin, AL Hemonnot, V Seube, N Linck… - Frontiers in Synaptic …, 2020 - frontiersin.org
Neuronal hippocampal cultures are simple and valuable models for studying neuronal
function. While embryonic cultures are widely used for different applications, mouse postnatal …
function. While embryonic cultures are widely used for different applications, mouse postnatal …
Degradation of cAMP-responsive element–binding protein by the ubiquitin-proteasome pathway contributes to glucotoxicity in β-cells and human pancreatic islets
…, B Vandewalle, C Tourrel-Cuzin, C Broca, N Linck… - Diabetes, 2009 - Am Diabetes Assoc
OBJECTIVE In type 2 diabetes, chronic hyperglycemia is detrimental to β-cells, causing
apoptosis and impaired insulin secretion. The transcription factor cAMP-responsive element–…
apoptosis and impaired insulin secretion. The transcription factor cAMP-responsive element–…
[PDF][PDF] Microglial P2X4 receptors are essential for spinal neurons hyperexcitability and tactile allodynia in male and female neuropathic mice
D Gilabert, A Duveau, S Carracedo, N Linck, A Langla… - IScience, 2023 - cell.com
In neuropathic pain, recent evidence has highlighted a sex-dependent role of the P2X4
receptor in spinal microglia in the development of tactile allodynia following nerve injury. Here, …
receptor in spinal microglia in the development of tactile allodynia following nerve injury. Here, …