Atrial fibrillation (AF) affects more than 33 million individuals worldwide 1 and has a complex
heritability 2 . We conducted the largest meta-analysis of genome-wide association studies (…

It is generally accepted that healthy cells degrade their own mitochondria. Here, we report
that retinal ganglion cell axons of WT mice shed mitochondria at the optic nerve head (ONH), …

Atrial fibrillation affects more than 33 million people worldwide and increases the risk of
stroke, heart failure, and death 1 , 2 . Fourteen genetic loci have been associated with atrial …

Fasting glucose and insulin are intermediate traits for type 2 diabetes. Here we explore the
role of coding variation on these traits by analysis of variants on the HumanExome BeadChip …

Background Genome-wide association studies conducted on QRS duration, an electrocardiographic
measurement associated with heart failure and sudden cardiac death, have led to …

Genome-wide association studies have identified> 50 common variants associated with kidney
function, but these variants do not fully explain the variation in eGFR. We performed a two…

OBJECTIVE Obesity and metabolic syndrome are associated with major adverse
cardiovascular events (MACE). However, whether distinct metabolic phenotypes differ in risk for …

Background QT interval, measured through a standard ECG, captures the time it takes for
the cardiac ventricles to depolarize and repolarize. JT interval is the component of the QT …

Objective The purpose of this study was to establish a biorepository of clinical, metabolomic,
and microbiome samples from adolescents with obesity as they undergo lifestyle …

Resting heart rate is a heritable trait, and an increase in heart rate is associated with increased
mortality risk. Genome-wide association study analyses have found loci associated with …