Elucidating the wiring diagram of the human cell is a central goal of the postgenomic era.
We combined genome engineering, confocal live-cell imaging, mass spectrometry, and data …

Targeted proteomics is a convenient method determining enzyme expression levels, but a
quantitative analysis of these proteomic data has not been fully explored yet. Here, we …

We designed an epi-illumination SPIM system that uses a single objective and has a
sample interface identical to that of an inverted fluorescence microscope with no additional …

This paper reports the design, development, and magnetic resonance imaging (MRI)
compatibility evaluation of an actuated transrectal prostate robot for MRI-guided needle …

The cell cycle, over which cells grow and divide, is a fundamental process of life. Its dysregulation
has devastating consequences, including cancer 1 , 2 – 3 . The cell cycle is driven by …

Magnetic Resonance Imaging (MRI) guided prostate biopsy and brachytherapy has been
introduced in order to enhance the cancer detection and treatment. For the accurate needle …

Cardiac fibroblasts and their activated derivatives, myofibroblasts, play a critical role in wound
healing after myocardial injury and often contribute to long-term pathological outcomes, …

We report quantitative label-free imaging with phase and polarization (QLIPP) for simultaneous
measurement of density, anisotropy, and orientation of structures in unlabeled live cells …

CRISPR/Cas technologies have transformed our ability to add functionality to the genome
by knock-in of payload via homology-directed repair (HDR). However, a systematic and …

Mitochondria in cardiac myocytes are critical for generating ATP to meet the high metabolic
demands associated with sarcomere shortening. Distinct remodeling of mitochondrial …