Biobanks facilitate genome-wide association studies (GWASs), which have mapped genomic
loci across a range of human diseases and traits. However, most biobanks are primarily …

Background International guidelines for variant interpretation in Mendelian disease set stringent
criteria to report a variant as (likely) pathogenic, prioritising control of false-positive rate …

Meta-analysis is pervasively used to combine multiple genome-wide association studies (GWASs).
Fine-mapping of meta-analysis studies is typically performed as in a single-cohort …

Background: Cancer therapy–induced cardiomyopathy (CCM) is associated with cumulative
drug exposures and preexisting cardiovascular disorders. These parameters incompletely …

Polygenic risk scores (PRSs) have been widely explored in precision medicine. However,
few studies have thoroughly investigated their best practices in global populations across …

Background Sleep apnoea, a common sleep-disordered breathing condition, is characterised
by upper airway collapse during sleep resulting in transient hypoxia, hypoperfusion of the …

Purpose: Observational studies have suggested that individuals with pre-existing sleep
apnea (SA) have up to double the risk of developing glaucoma than individuals without SA. …

Primary open-angle glaucoma (POAG) is a complex eye disease characterized by progressive
loss of optic nerve function that, if untreated, ultimately leads to irreversible blindness. To …

Study Objectives Despite its association with severe health conditions, the etiology of sleep
apnea (SA) remains understudied. This study sought to identify genetic variants robustly …

Skin aging is a natural process that occurs over time, but can be accelerated by sun
exposure. Measuring skin age in a large population can provide insight into the extent of skin …