Assembly of the eIF4E/eIF4G complex has a central role in the regulation of gene expression
at the level of translation initiation. This complex is regulated by the 4E-BPs, which …

The eukaryotic initiation factor 4G (eIF4G) is the core of a multicomponent switch controlling
gene expression at the level of translation initiation. It interacts with the small ribosomal …

A common key regulator of oncogenic signaling pathways in multiple tumor types is the
unique isomerase Pin1. However, available Pin1 inhibitors lack the required specificity and …

The technique of fluorescence polarization (FP) is based on the observation that when a
fluorescently labeled molecule is excited by polarized light, it emits light with a degree of …

Considerable evidence indicates that the general blockade of protein synthesis prevents
both the initial consolidation and the postretrieval reconsolidation of long-term memories. …

Drugs that inhibit RAF / MEK signaling, such as vemurafenib, elicit profound but often temporary
anti‐tumor responses in patients with BRAF V 600E melanoma. Adaptive responses to …

Variants in the leucine-rich repeat kinase 2 (LRRK2) gene are associated with increased
risk for familial and sporadic Parkinson’s disease (PD). Pathogenic variants in LRRK2, …

The mTORC1 pathway is a central regulator of cell growth, and defective mTORC1 regulation
plays a causative role in a variety of human diseases, including cancer, tumor syndromes …

Eukaryotic translation initiation factor 2B (eIF2B) is a key component of the integrated stress
response (ISR), which regulates protein synthesis and stress granule formation in response …

Kaposi’s sarcoma–associated herpesvirus (KSHV) has a causative role in several human
malignancies, especially in immunocompromised hosts. KSHV latently infects tumor cells and …