Messenger RNA encodes cellular function and phenotype. In the context of human cancer, it
defines the identities of malignant cells and the diversity of tumor tissue. We studied 72,501 …

Single-cell transcriptomics has allowed unprecedented resolution of cell types/states in the
human lung, but their spatial context is less well defined. To (re)define tissue architecture of …

Tissue-resident immune cells are important for organ homeostasis and defense. The epithelium
may contribute to these functions directly or by cross-talk with immune cells. We used …

The function of a cell is defined by its intrinsic characteristics and its niche: the tissue
microenvironment in which it dwells. Here we combine single-cell and spatial transcriptomics data …

Rapid COVID-19 diagnosis in the hospital is essential, although this is complicated by 30%–50%
of nose/throat swabs being negative by SARS-CoV-2 nucleic acid amplification testing (…

IgG antibodies cause inflammation and organ damage in autoimmune diseases such as
systemic lupus erythematosus (SLE). We investigated the metabolic profile of macrophages …

The prostate gland produces prostatic fluid, high in zinc and citrate and essential for the
maintenance of spermatozoa. Prostate cancer is a common condition with limited treatment …

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike N-terminal domain
(NTD) remains poorly characterized despite enrichment of mutations in this region across …

CD4 + T helper (Th) differentiation is regulated by diverse inputs, including the vitamin A
metabolite retinoic acid (RA). RA acts through its receptor RARα to repress transcription of …

Multiple distinct cell types of the human lung and airways have been defined by single cell
RNA sequencing (scRNAseq). Here we present a multi-omics spatial lung atlas to define …