Determining protein levels in each tissue and how they compare with RNA levels is important
for understanding human biology and disease as well as regulatory processes that control …

Long non-coding RNA (lncRNA) genes have well-established and important impacts on
molecular and cellular functions. However, among the thousands of lncRNA genes, it is still a …

Associations between genetic variation and traits are often in noncoding regions with strong
linkage disequilibrium (LD), where a single causal variant is assumed to underlie the …

Gene co-expression networks capture biologically important patterns in gene expression
data, enabling functional analyses of genes, discovery of biomarkers, and interpretation of …

INTRODUCTION The human genome contains tens of thousands of rare (minor allele frequency
<1%) variants, some of which contribute to disease risk. Using 838 samples with whole-…

Background Population structure among study subjects may confound genetic association
studies, and lack of proper correction can lead to spurious findings. The Genotype-Tissue …

Type I interferons (IFNs) induce hundreds of IFN-stimulated genes (ISGs) in response to viral
infection. Induction of these ISGs must be regulated for an efficient and controlled antiviral …

Noncoding variants of presumed regulatory function contribute to the heritability of
neuropsychiatric disease. A total of 2,221 noncoding variants connected to risk for ten …

The impact of inherited genetic variation on gene expression in humans is well-established.
The majority of known expression quantitative trait loci (eQTLs) impact expression of local …

Expression quantitative trait locus (eQTL) mapping provides a powerful means to identify
functional variants influencing gene expression and disease pathogenesis. We report the …