Human gut Bacteroidetes can utilize yeast mannan through a selfish mechanism

…, MJ Temple, Y Zhu, EA Cameron, NA Pudlo, NT Porter… - Nature, 2015 - nature.com
Yeasts, which have been a component of the human diet for at least 7,000 years, possess an
elaborate cell wall α-mannan. The influence of yeast mannan on the ecology of the human …

The critical roles of polysaccharides in gut microbial ecology and physiology

NT Porter, EC Martens - Annual review of microbiology, 2017 - annualreviews.org
The human intestine harbors a dense microbial ecosystem (microbiota) that is different
between individuals, dynamic over time, and critical for aspects of health and disease. Dietary …

Phase-variable capsular polysaccharides and lipoproteins modify bacteriophage susceptibility in Bacteroides thetaiotaomicron

NT Porter, AJ Hryckowian, BD Merrill, JJ Fuentes… - Nature …, 2020 - nature.com
A variety of cell surface structures dictate interactions between bacteria and their environment,
including their viruses (bacteriophages). Members of the human gut Bacteroidetes …

[PDF][PDF] Colitogenic Bacteroides thetaiotaomicron antigens access host immune cells in a sulfatase-dependent manner via outer membrane vesicles

CA Hickey, KA Kuhn, DL Donermeyer, NT Porter… - Cell host & …, 2015 - cell.com
Microbes interact with the host immune system via several potential mechanisms. One
essential step for each mechanism is the method by which intestinal microbes or their antigens …

Investigation and alteration of organic acid synthesis pathways in the mammalian gut symbiont Bacteroides thetaiotaomicron

NT Porter, J Larsbrink - Microbiology Spectrum, 2022 - Am Soc Microbiol
Members of the gut-dwelling Bacteroides genus have remarkable abilities in degrading a
diverse set of fiber polysaccharide structures, most of which are found in the mammalian diet. …

Reciprocal prioritization to dietary glycans by gut bacteria in a competitive environment promotes stable coexistence

YE Tuncil, Y Xiao, NT Porter, BL Reuhs, EC Martens… - MBio, 2017 - Am Soc Microbiol
When presented with nutrient mixtures, several human gut Bacteroides species exhibit
hierarchical utilization of glycans through a phenomenon that resembles catabolite repression. …

[PDF][PDF] A subset of polysaccharide capsules in the human symbiont Bacteroides thetaiotaomicron promote increased competitive fitness in the mouse gut

NT Porter, P Canales, DA Peterson, EC Martens - Cell host & microbe, 2017 - cell.com
Capsular polysaccharides (CPSs) play multiple roles in protecting bacteria from host and
environmental factors, and many commensal bacteria can produce multiple capsule types. To …

Bacteroides thetaiotaomicron

NT Porter, AS Luis, EC Martens - Trends in microbiology, 2018 - cell.com
This infographic on Bacteroides thetaiotaomicron (Bt) explores the ability of this microbe to
digest a broad array of complex carbohydrates, alter its surface features, and its emerging …

[PDF][PDF] Bacteroides thetaiotaomicron-infecting bacteriophage isolates inform sequence-based host range predictions

AJ Hryckowian, BD Merrill, NT Porter, W Van Treuren… - Cell Host & Microbe, 2020 - cell.com
Our emerging view of the gut microbiome largely focuses on bacteria, while less is known
about other microbial components, such as bacteriophages (phages). Though phages are …

Polysaccharide capsules equip the human symbiont Bacteroides thetaiotaomicron to modulate immune responses to a dominant antigen in the intestine

S Hsieh, NT Porter, DL Donermeyer… - The Journal of …, 2020 - journals.aai.org
Bacteria express multiple diverse capsular polysaccharides (CPSs) for protection against
environmental and host factors, including the host immune system. Using a mouse TCR …