Cellular identity in complex multicellular organisms is determined in part by the physical
organization of cells. However, large-scale investigation of the cellular interactome remains …

To address how genetic variation alters gene expression in complex cell mixtures, we
developed direct nuclear tagmentation and RNA sequencing (DNTR-seq), which enables whole-…

X-chromosome inactivation and X-upregulation are the fundamental modes of chromosome-wide
gene regulation that collectively achieve dosage compensation in mammals, but the …

Mammals, including humans, prepare for sleep by nesting and/or curling up, creating
microclimates of skin warmth. To address whether external warmth induces sleep through defined …

Background Navigation systems have the potential to facilitate intraoperative orientation
and recognition of anatomical structures. Intraoperative accuracy of navigation in …

Joint single-cell measurements of gene expression and DNA regulatory element activity
holds great promise as a tool to understand transcriptional regulation. Towards this goal we …

In a SIM-swap attack, a hacker uses text messages sent to a wireless customer's phone
number to reset passwords and access critical accounts. These SIM-swap attacks are often …

The microRNA-34a is a well-studied tumor suppressor microRNA (miRNA) and a direct
downstream target of TP53 with roles in several pathways associated with oncogenesis, such as …

X-chromosome inactivation (XCI) and upregulation (XCU) are the major opposing
chromosome-wide modes of gene regulation that collectively achieve dosage compensation in …

Mammalian X-chromosome dosage balance is regulated by X-chromosome inactivation (XCI)
and X-chromosome upregulation (XCU), but the dynamics of XCU as well as the interplay …