[HTML][HTML] Large-scale recombinant production of the SARS-CoV-2 proteome for high-throughput and structural biology applications

…, D Maurin, SW McNutt, NC Mebus-Antunes… - Frontiers in molecular …, 2021 - frontiersin.org
The highly infectious disease COVID-19 caused by the Betacoronavirus SARS-CoV-2 poses
a severe threat to humanity and demands the redirection of scientific efforts and criteria to …

Comprehensive fragment screening of the SARS‐CoV‐2 proteome explores novel chemical space for drug development

…, Y Li, N Cunha MebusAntunes… - Angewandte Chemie …, 2022 - Wiley Online Library
SARS‐CoV‐2 (SCoV2) and its variants of concern pose serious challenges to the public
health. The variants increased challenges to vaccines, thus necessitating for development of …

Insights into the specificity for the interaction of the promiscuous SARS-CoV-2 nucleocapsid protein N-terminal domain with deoxyribonucleic acids

…, A de Luna Marques, NC Mebus-Antunes… - International journal of …, 2022 - Elsevier
The SARS-CoV-2 nucleocapsid protein (N) is a multifunctional promiscuous nucleic acid-binding
protein, which plays a major role in nucleocapsid assembly and discontinuous RNA …

Structure insights, thermodynamic profiles, dsDNA melting activity, and liquid-liquid phase separation of the SARS-CoV-2 nucleocapsid N-terminal domain binding to …

…, A de Luna Marques, NC Mebus-Antunes… - bioRxiv, 2021 - biorxiv.org
The SARS-CoV-2 nucleocapsid protein (N) is a multifunctional promiscuous nucleic acid-binding
protein, which plays a major role in nucleocapsid assembly and discontinuous RNA …

[HTML][HTML] Biophysical studies of RNA: DNA: DNA triplexes and characterization of riboswitches in cell-free transcription-translation systems

JK Bains - 2023 - publikationen.ub.uni-frankfurt.de
RNA research is very important since RNA molecules are involved in various gene regulatory
mechanisms as well as pathways of cell physiology and disease development.1 RNAs …

[HTML][HTML] Client-Chaperone Selectivity, Solubility, and Hydrogel Characteristics of Human Crystallins and the Properties of D1-PSI

MA Sprague-Piercy - 2021 - search.proquest.com
For the eye lens to function correctly, it must be transparent and refract visible light strongly
enough to form an image on the retina. The bulk of this unique tissue is made of layers of …

[PDF][PDF] Large-Scale Recombinant Production of the SARS-CoV-2 Proteome for High-Throughput and Structural Biology Applications

H Schwalbe, M Hengesbach, A Schlundt - pure-oai.bham.ac.uk
The highly infectious disease COVID-19 caused by the Betacoronavirus SARS-CoV-2 poses
a severe threat to humanity and demands the redirection of scientific efforts and criteria to …