The effectiveness of stem cell therapies has been hampered by cell death and limited
control over fate. These problems can be partially circumvented by using macroporous …

Stem cells sense and respond to the mechanical properties of the extracellular matrix.
However, both the extent to which extracellular-matrix mechanics affect stem-cell fate in three-…

Biomaterials, traditionally defined as materials used in medical devices, have been used
since antiquity, but recently their degree of sophistication has increased significantly. …

Natural extracellular matrices (ECMs) are viscoelastic and exhibit stress relaxation. However,
hydrogels used as synthetic ECMs for three-dimensional (3D) culture are typically elastic. …

Studies of cellular mechanotransduction have converged upon the idea that cells sense
extracellular matrix (ECM) elasticity by gauging resistance to the traction forces they exert on the …

Porous biomaterials have been widely used as scaffolds in tissue engineering and cell-based
therapies. The release of biological agents from conventional porous scaffolds is typically …

The treatment of challenging fractures and large osseous defects presents a formidable
problem for orthopaedic surgeons. Tissue engineering/regenerative medicine approaches seek …

Drug discovery and development are hampered by high failure rates attributed to the reliance
on non-human animal models employed during safety and efficacy testing. A fundamental …

Developing technologies for efficient and scalable disruption of gene expression will
provide powerful tools for studying gene function, developmental pathways, and disease …

Cancer vaccines typically depend on cumbersome and expensive manipulation of cells in
the laboratory, and subsequent cell transplantation leads to poor lymph-node homing and …