User profiles for Nathaniel I. Bloom

Nathaniel Bloom

Stanford Immunology
Verified email at stanford.edu
Cited by 1281

[PDF][PDF] SARS-CoV-2 vaccination induces immunological T cell memory able to cross-recognize variants from Alpha to Omicron

…, Z Zhang, JM Dan, ED Yu, N Methot, NI Bloom… - Cell, 2022 - cell.com
We address whether T cell responses induced by different vaccine platforms (mRNA-1273,
BNT162b2, Ad26.COV2.S, and NVX-CoV2373) cross-recognize early SARS-CoV-2 variants. …

[PDF][PDF] Humoral and cellular immune memory to four COVID-19 vaccines

…, J Chang, EA Escarrega, C Kim, B Goodwin, NI Bloom… - Cell, 2022 - cell.com
Multiple COVID-19 vaccines, representing diverse vaccine platforms, successfully protect
against symptomatic COVID-19 cases and deaths. Head-to-head comparisons of T cell, B cell, …

SARS-CoV-2 infection generates tissue-localized immunological memory in humans

…, Y Kato, M Kubota, R Matsumoto, NI Bloom… - Science …, 2021 - science.org
Adaptive immune responses to SARS-CoV-2 infection have been extensively characterized
in blood; however, most functions of protective immunity must be accomplished in tissues. …

A particulate saponin/TLR agonist vaccine adjuvant alters lymph flow and modulates adaptive immunity

…, R Bastidas, J Bhiman, C Linde, NI Bloom… - Science …, 2021 - science.org
Saponins are potent and safe vaccine adjuvants, but their mechanisms of action remain
incompletely understood. Here, we explored the properties of several saponin formulations, …

Memory B-cell development after asymptomatic or mild symptomatic SARS-CoV-2 infection

Y Kato, NI Bloom, P Sun, CA Balinsky… - The Journal of …, 2023 - academic.oup.com
Background The development of memory B cells after asymptomatic severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) infection is not well understood. Methods We …

[PDF][PDF] Asymptomatic or symptomatic SARS-CoV-2 infection plus vaccination confers increased adaptive immunity to variants of concern

…, A Grifoni, CA Balinsky, S Vangeti, A Tarke, NI Bloom… - Iscience, 2022 - cell.com
The ongoing evolution of SARS-CoV-2 requires monitoring the capability of immune
responses to cross-recognize Variants of Concern (VOC). In this cross-sectional study, we …

Mpox vaccine and infection-driven human immune signatures: an immunological analysis of an observational study

H Cohn, N Bloom, GY Cai, JJ Clark, A Tarke… - The Lancet Infectious …, 2023 - thelancet.com
Background Monkeypox virus has recently infected more than 88 000 people, raising concerns
about our preparedness against this emerging viral pathogen. Licensed and approved …

[HTML][HTML] Preserved SARS-CoV-2 vaccine cell-mediated immunogenicity in patients with inflammatory bowel disease on immune-modulating therapies

BS Boland, B Goodwin, Z Zhang, N Bloom… - Clinical and …, 2022 - journals.lww.com
Immune-modulating medications for inflammatory bowel diseases (IBDs) have been
associated with suboptimal vaccine responses. There are conflicting data with SARS-CoV-2 …

[HTML][HTML] SARS-CoV-2 monoclonal antibody treatment followed by vaccination shifts human memory B cell epitope recognition suggesting antibody feedback

CH Coelho, N Bloom, SI Ramirez, UM Parikh, A Heaps… - bioRxiv, 2023 - ncbi.nlm.nih.gov
Therapeutic anti-SARS-CoV-2 monoclonal antibodies (mAbs) have been extensively
studied in humans, but the impact on immune memory of mAb treatment during an ongoing …

Mpox vaccine and infection-driven human immune signatures

H Cohn, N Bloom, G Cai, J Clark, A Tarke… - medRxiv, 2023 - medrxiv.org
Background Mpox (formerly known as monkeypox) outbreaks outside endemic areas peaked
in July 2022, infecting > 85,000 people and raising concerns about our preparedness …