The transient receptor potential superfamily of ion channels (TRP channels) is widely
recognized for the roles its members play in sensory nervous systems. However, the incredible …

The basic mechanisms underlying noxious cold perception are not well understood. We
developed Drosophila assays for noxious cold responses. Larvae respond to near-freezing …

Chemically induced nociception has not yet been studied intensively in genetically tractable
models. Hence, our goal was to establish a Drosophila assay that can be used to study the …

Transient receptor potential melastatins (TRPMs) are most well known as cold and menthol
sensors, but are in fact broadly critical for life, from ion homeostasis to reproduction. Yet, the …

Transient receptor potential (TRP) cation channels are highly conserved, polymodal sensors
which respond to a wide variety of stimuli. Perhaps most notably, TRP channels serve …

Insect odorant receptors and gustatory receptors define a superfamily of seven transmembrane
domain ion channels (referred to here as 7TMICs), with homologs identified across …

Individual sensory neurons can be tuned to many stimuli, each driving unique, stimulusrelevant
behaviors, and the ability of multimodal nociceptor neurons to discriminate between …

Calcium (Ca2+) plays a pivotal role in modulating neuronal-mediated responses to modality-specific
sensory stimuli. Recent studies in Drosophila reveal class III (CIII) multidendritic (md…

Low temperatures can be fatal to insects, but many species have evolved the ability to cold
acclimate, thereby increasing their cold tolerance. It has been previously shown that …

Many proteins exist in the so-called "twilight zone" of sequence alignment, where low
pairwise sequence identity makes it difficult to determine homology and phylogeny. As protein …