Helicobacter pylori infection is associated with a variety of clinical outcomes including gastric
cancer and duodenal ulcer disease 1 . The reasons for this variation are not clear, but the …

Too many reports of associations between genetic variants and common cancer sites and
other complex diseases are false positives. A major reason for this unfortunate situation is the …

During the past several decades, an increasing incidence of thyroid cancer has been reported
in many parts of the world. To date, no study has compared the trends in thyroid cancer …

Benzene is known to have toxic effects on the blood and bone marrow, but its impact at
levels below the US occupational standard of 1 part per million (ppm) remains uncertain. In a …

Background Many reported associations between common genetic polymorphisms and
complex diseases have not been confirmed in subsequent studies. An exception could be the …

Bladder cancer has been associated with exposure to chlorination by-products in drinking
water, and experimental evidence suggests that exposure also occurs through inhalation and …

The Agricultural Health Study, a large prospective cohort study has been initiated in North
Carolina and Iowa. The objectives of this study are to: 1) identify and quantify cancer risks …

Purpose: To provide a comprehensive, thorough analysis of somatic mutation and promoter
hypermethylation of the von Hippel-Lindau (VHL) gene in the cancer genome, unique to …

Background Most studies of the association between diesel exhaust exposure and lung cancer
suggest a modest, but consistent, increased risk. However, to our knowledge, no study to …

Although cancer is a major cause of morbidity and mortality in most nations, the spectrum of
cancer occurrence varies substantially worldwide. Most previous epidemiologic studies …