User profiles for Nathaniel Talledge
 | Nathaniel TalledgeAltos Labs - Bay Area Institute Verified email at altoslabs.com Cited by 485 |
Structure and membrane remodeling activity of ESCRT-III helical polymers
The endosomal sorting complexes required for transport (ESCRT) proteins mediate fundamental
membrane remodeling events that require stabilizing negative membrane curvature. …
membrane remodeling events that require stabilizing negative membrane curvature. …
[PDF][PDF] Membrane constriction and thinning by sequential ESCRT-III polymerization
The Endosomal Sorting Complexes Required for Transport (ESCRTs) mediate diverse
membrane remodeling events. These activities typically require ESCRT-III proteins to stabilize …
membrane remodeling events. These activities typically require ESCRT-III proteins to stabilize …
[HTML][HTML] Anisotropic ESCRT-III architecture governs helical membrane tube formation
ESCRT-III proteins assemble into ubiquitous membrane-remodeling polymers during many
cellular processes. Here we describe the structure of helical membrane tubes that are …
cellular processes. Here we describe the structure of helical membrane tubes that are …
Structural inhibition of dynamin-mediated membrane fission by endophilin
10.7554/eLife.26856.001 Dynamin, which mediates membrane fission during endocytosis,
binds endophilin and other members of the Bin-Amphiphysin-Rvs (BAR) protein family. How …
binds endophilin and other members of the Bin-Amphiphysin-Rvs (BAR) protein family. How …
Inhibiting HTLV-1 protease: a viable antiviral target
Human T-cell lymphotropic virus type 1 (HTLV-1) is a retrovirus that can cause severe
paralytic neurologic disease and immune disorders as well as cancer. An estimated 20 million …
paralytic neurologic disease and immune disorders as well as cancer. An estimated 20 million …
[PDF][PDF] Slow receptor binding of the noncytopathic HIV-2UC1 Envs is balanced by long-lived activation state and efficient fusion activity
…, A Chov, H Cervera, A Block, C Gu, N Talledge… - Cell reports, 2020 - cell.com
Many HIV strains downregulate the levels of CD4 receptor on the surface of infected cells to
prevent superinfection. In contrast, the rare HIV-2 UC1 strain is noncytopathic and has no …
prevent superinfection. In contrast, the rare HIV-2 UC1 strain is noncytopathic and has no …
[HTML][HTML] Molecular Biology and Diversification of Human Retroviruses
ME Meissner, N Talledge, LM Mansky - Frontiers in virology, 2022 - frontiersin.org
Studies of retroviruses have led to many extraordinary discoveries that have advanced our
understanding of not only human diseases, but also molecular biology as a whole. The most …
understanding of not only human diseases, but also molecular biology as a whole. The most …
The ESCRT-III proteins IST1 and CHMP1B assemble around nucleic acids
N Talledge, J McCullough, D Wenzel, HC Nguyen… - Biorxiv, 2018 - biorxiv.org
ESCRT-III proteins can promote inside-out or outside-in membrane tubulation and fission. In
addition, several observations suggest that ESCRT factors may also associate with nucleic …
addition, several observations suggest that ESCRT factors may also associate with nucleic …
HIV-2 Immature Particle Morphology Provides Insights into Gag Lattice Stability and Virus Maturation
N Talledge, H Yang, K Shi, R Coray, G Yu… - Journal of Molecular …, 2023 - Elsevier
Retrovirus immature particle morphology consists of a membrane enclosed, pleomorphic,
spherical and incomplete lattice of Gag hexamers. Previously, we demonstrated that human …
spherical and incomplete lattice of Gag hexamers. Previously, we demonstrated that human …
Human immunodeficiency virus type 2 capsid protein mutagenesis defines the determinants for Gag–Gag interactions
Human immunodeficiency virus (HIV) Gag drives virus particle assembly. The capsid (CA)
domain is critical for Gag multimerization, and encodes key residues that dictate Gag-Gag …
domain is critical for Gag multimerization, and encodes key residues that dictate Gag-Gag …