Background Baricitinib is an oral selective Janus kinase 1/2 inhibitor with known anti-inflammatory
properties. This study evaluates the efficacy and safety of baricitinib in combination …

Antibody titers against SARS-CoV-2 slowly wane over time. Here, we examined how time
affects antibody potency. To assess the impact of antibody maturation on durable neutralizing …

Efavirenz (EFV) is metabolized by cytochrome P450 2B6 (CYP2B6) in the liver. We analyzed
the genotypes of CYP2B6 and their contribution to plasma EFV concentrations in 35 EFV-…

Identifying the host genetic factors underlying severe COVID-19 is an emerging challenge 1
, 2 , 3 , 4 – 5 . Here we conducted a genome-wide association study (GWAS) involving 2,393 …

On examination he was afebrile. His pulse was 72 beats per minute and his blood pressure
was 170/100 mmHg. His jugular venous pressure was not raised. There was no oedema. …

To assess the possible influence of human immunodeficiency virus type 1 (HIV-1) infection
on the clinical course of acute hepatitis A virus (HAV) infection, 15 HIV-1–infected …

Although hypervirulent Klebsiella pneumoniae (hvKp) has been associated with severe
community-acquired infections that occur among relatively healthy individuals, information about …

Tenofovir disoproxil fumarate (TDF) is renally excreted by a combination of glomerular filtration
and active tubular secretion, and its renal safety profiles have been reported based on a …

We detected (1 --> 3) beta-D-glucan (beta-glucan), which is one of the major components of
the cyst wall of Pneumocystis carinii, in sera obtained from patients with P. carinii …

HLA‐A, ‐C, ‐B, and ‐DRB1 genotypes were analyzed in 178 Japanese COVID‐19 patients
to investigate the association of HLA with severe COVID‐19. Analysis of 32 common HLA …