Patient-derived xenografts (PDXs) and patient-derived organoids (PDOs) have been shown
to model clinical response to cancer therapy. However, it remains challenging to use these …

In vitro tissue models hold great promise for modeling diseases and drug responses. Here,
we used emulsion microfluidics to form micro-organospheres (MOSs), which are droplet-…

Myeloid cells are increasingly recognized as major players in transplant rejection. Here, we
used a murine kidney transplantation model and single cell transcriptomics to dissect the …

The Zebrafish Posterior Lateral Line primordium migrates in a channel between the skin
and somites. Its migration depends on the coordinated movement of its mesenchymal-like …

Background In kidney transplantation, early allograft inflammation impairs long-term allograft
function. However, precise mediators of early kidney allograft inflammation are unclear, …

Perfusable microvascular networks offer promising three-dimensional in vitro models to
study normal and compromised vascular tissues as well as phenomena such as cancer cell …

During embryonic development, cells must navigate through diverse three-dimensional
environments robustly and reproducibly. The zebrafish posterior lateral line primordium (PLLp), …

e15027 Background: Lung cancer is the leading cause of death worldwide. Metastatic lung
cancer patients often relapse or grow refractory to chemotherapy, radiotherapy, and …

Methods MOS were generated from lung, kidney, and colorectal cancer patients. The
composition and function of patient tumor-resident immune cells in MOS were characterized by …

It is with great respect and devotion, I express my sincere gratitude and indebtedness to Dr.
Deepa S. Nair, Assistant Professor and Head, Department of Plantation Crops and Spices, …