Decoding myofibroblast origins in human kidney fibrosis
…, JR Wilson-Kanamori, M Halder, Y Xu, N Kabgani… - Nature, 2021 - nature.com
Kidney fibrosis is the hallmark of chronic kidney disease progression; however, at present
no antifibrotic therapies exist 1 , 2 – 3 . The origin, functional heterogeneity and regulation of …
no antifibrotic therapies exist 1 , 2 – 3 . The origin, functional heterogeneity and regulation of …
[HTML][HTML] Dysfunction of the key ferroptosis-surveilling systems hypersensitizes mice to tubular necrosis during acute kidney injury
…, S Doll, I Ingold, B Proneth, C Daniel, N Kabgani… - Nature …, 2021 - nature.com
Acute kidney injury (AKI) is morphologically characterized by a synchronized plasma membrane
rupture of cells in a specific section of a nephron, referred to as acute tubular necrosis (…
rupture of cells in a specific section of a nephron, referred to as acute tubular necrosis (…
[HTML][HTML] Chromatin-accessibility estimation from single-cell ATAC-seq data with scOpen
A major drawback of single-cell ATAC-seq (scATAC-seq) is its sparsity, ie, open chromatin
regions with no reads due to loss of DNA material during the scATAC-seq protocol. Here, we …
regions with no reads due to loss of DNA material during the scATAC-seq protocol. Here, we …
A tautomerase-null macrophage migration-inhibitory factor (MIF) gene knock-in mouse model reveals that protein interactions and not enzymatic activity mediate MIF …
…, C Schlander, N Kabgani… - … and cellular biology, 2009 - Am Soc Microbiol
Macrophage migration-inhibitory factor (MIF) is an upstream regulator of innate immunity
and a potential molecular link between inflammation and cancer. The unusual structural …
and a potential molecular link between inflammation and cancer. The unusual structural …
[HTML][HTML] Novel parietal epithelial cell subpopulations contribute to focal segmental glomerulosclerosis and glomerular tip lesions
Beside the classical flat parietal epithelial cells (PECs), we investigated proximal tubular
epithelial-like cells, a neglected subgroup of PECs. These cells, termed cuboidal PECs, make …
epithelial-like cells, a neglected subgroup of PECs. These cells, termed cuboidal PECs, make …
Altered vitamin K biodistribution and metabolism in experimental and human chronic kidney disease
…, N Rapp, C Drechsler, N Kabgani… - Kidney International, 2022 - Elsevier
Chronic kidney disease (CKD) is accompanied with extensive cardiovascular calcification,
in part correlating with functional vitamin K deficiency. Here, we sought to determine causes …
in part correlating with functional vitamin K deficiency. Here, we sought to determine causes …
Investigations of glucocorticoid action in GN
…, C Van Roeyen, K Leuchtle, N Kabgani… - Journal of the …, 2017 - journals.lww.com
For several decades, glucocorticoids have been used empirically to treat rapid progressive
GN. It is commonly assumed that glucocorticoids act primarily by dampening the immune …
GN. It is commonly assumed that glucocorticoids act primarily by dampening the immune …
[HTML][HTML] Primary cultures of glomerular parietal epithelial cells or podocytes with proven origin
N Kabgani, T Grigoleit, K Schulte, A Sechi… - PloS one, 2012 - journals.plos.org
Parietal epithelial cells (PECs) are crucially involved in the pathogenesis of rapidly progressive
glomerulonephritis (RPGN) as well as in focal and segmental glomerulosclerosis (FSGS)…
glomerulonephritis (RPGN) as well as in focal and segmental glomerulosclerosis (FSGS)…
The transcription factor Dach1 is essential for podocyte function
…, K Amann, MJ Moeller, N Kabgani… - Journal of cellular …, 2018 - Wiley Online Library
Dedifferentiation and loss of podocytes are the major cause of chronic kidney disease. Dach1,
a transcription factor that is essential for cell fate, was found in genome‐wide association …
a transcription factor that is essential for cell fate, was found in genome‐wide association …
Chromatin-accessibility estimation from single-cell ATAC data with scOpen
A major drawback of single cell ATAC (scATAC) are the so-called dropout events, ie open
chromatin regions with no reads due to loss of DNA material during the scATAC-seq protocol. …
chromatin regions with no reads due to loss of DNA material during the scATAC-seq protocol. …