User profiles for Nazli Akin

Nazli Akin

Vrije Universiteit of Brussel
Verified email at vub.be
Cited by 464

GnRH agonist leuprolide acetate does not confer any protection against ovarian damage induced by chemotherapy and radiation in vitro

G Bildik, N Akin, F Senbabaoglu, GN Sahin… - Human …, 2015 - academic.oup.com
STUDY QUESTION Is there any in vitro evidence for or against ovarian protection by co-administration
of a GnRH agonist with chemotherapy in human? SUMMARY ANSWER The co-…

The magnitude of gonadotoxicity of chemotherapy drugs on ovarian follicles and granulosa cells varies depending upon the category of the drugs and the type of …

A Yuksel, G Bildik, F Senbabaoglu, N Akin… - Human …, 2015 - academic.oup.com
STUDY QUESTION Do different chemotherapy drugs exert the same magnitude of cytotoxicity
on dormant primordial follicles and the growing follicle fraction in the ovary in vivo and on …

FSH Stimulation promotes progesterone synthesis and output from human granulosa cells without luteinization

O Oktem, N Akin, G Bildik, K Yakin, E Alper… - Human …, 2017 - academic.oup.com
STUDY QUESTION Can granulosa cells produce progesterone (P) in response to FSH
stimulation? SUMMARY ANSWER FSH actively promotes P synthesis and output from granulosa …

Positive effects of amphiregulin on human oocyte maturation and its molecular drivers in patients with polycystic ovary syndrome

N Akin, AH Le, UDT Ha, S Romero… - Human …, 2022 - academic.oup.com
STUDY QUESTION Does use of medium containing amphiregulin improve meiotic maturation
efficiency in oocytes of women with polycystic ovary syndrome (PCOS) undergoing in vitro …

Characterization of carbohydrate metabolism in in vivo-and in vitro-grown and matured mouse antral follicles

AC Herta, L von Mengden, N Akin… - Biology of …, 2022 - academic.oup.com
Establishing an ideal human follicle culture system for oncofertility patients relies mainly on
animal models since donor tissue is scarce and often of suboptimal quality. The in vitro …

Glucose metabolism characterization during mouse in vitro maturation identifies alterations in cumulus cells

N Akin, L von Mengden, AC Herta… - Biology of …, 2021 - academic.oup.com
In vitro maturation (IVM) is an assisted reproduction technique with reduced hormone-related
side-effects. Several attempts to implement IVM in routine practice have failed, primarily …

Luteal granulosa cells from natural cycles are more capable of maintaining their viability, steroidogenic activity and LH receptor expression than those of stimulated …

G Bildik, N Akin, A Seyhan, Y Esmaeilian… - Human …, 2019 - academic.oup.com
STUDY QUESTION Are there any differences in the molecular characteristics of the luteal
granulosa cells (GC) obtained from stimulated versus non-stimulated (natural) IVF cycles that …

Effect of cumulin and super-GDF9 in standard and biphasic mouse IVM

N Akin, D Richani, X Liao, Y Zhao, AC Herta… - Journal of Assisted …, 2022 - Springer
Purpose In vitro maturation (IVM) is a technology that generates mature oocytes following
culture of immature cumulus-oocyte complexes (COC) in vitro. IVM is characterized by minimal …

Epigenetic variation in neonatal tissues in infants conceived using capacitation-in vitro maturation vs. in vitro fertilization

L Saucedo-Cuevas, MPQ Ma, AH Le, N Akin… - Fertility and …, 2024 - Elsevier
Objective To investigate alterations of the global DNA methylation profile in placenta, cord
blood, and neonatal buccal smears in infants conceived using in vitro maturation (IVM) with a …

Effects of lactate, super-GDF9, and low oxygen tension during bi-phasic in vitro maturation on the bioenergetic profiles of mouse cumulus–oocyte complex

N Akin, G Ates, L von Mengden, AC Herta… - Biology of …, 2023 - academic.oup.com
In vitro maturation (IVM) is an alternative assisted reproductive technology with reduced
hormone-related side effects and treatment burden compared to conventional IVF. Capacitation (…