Background Numerous studies indicate an association between neurodegenerative and
metabolic diseases. Although still a matter of debate, growing evidence from epidemiological …

Dysregulated glucagon secretion from pancreatic alpha-cells is a key feature of type-1 and
type-2 diabetes (T1D and T2D), yet our mechanistic understanding of alpha-cell function is …

The complement system is a crucial part of innate immune defenses against invading
pathogens. The blood-meal of the tick Rhipicephalus pulchellus lasts for days, and the tick must …

Background: Numerous studies indicate an association between neurodegenerative and
metabolic diseases. Although still a matter of debate, growing evidence from epidemiological …

Aims: Previous studies have reported the induction of the viperin in isolated human islets
exposed to proinflammatory cytokines and coxsackieviruses, as well as in the serum of people …

The complement system is a crucial part of innate immune defences against invading
pathogens. The blood-meal of the tick Rhipicephalus pulchellus lasts for days, and the tick must …

Aims: ACC1 couples glucose metabolism with de novo lipogenesis in lipogenic tissues, by
converting acetyl-CoA to malonyl-CoA. In β-cells, ACC1 plays a critical role in β-cell growth …

Background: In type 1 diabetes, insulin-producing pancreatic beta-cells are destroyed by an
autoimmune response. There are various cellular mechanisms, genes and environmental …

Background: Acetyl-CoA-Carboxylase (ACC1), the rate-limiting enzyme of de novo lipogenesis,
plays a critical role in beta cell growth and insulin secretion. In spite of plethora evidence …

Monoterpenes are a class of volatile organic compounds synthesized by plants. Their
characteristic scent possesses antimicrobial and anti-herbivore properties. In industry …