Background: Vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) is a
potent inducer of new blood vessel growth (angiogenesis) that contributes to the pathology …

Nuclease-resistant aptamers identified from randomized nucleic acid libraries represent a
novel class of drug candidates. Aptamers are synthesized chemically and therefore can be …

Interrogation of the human proteome in a highly multiplexed and efficient manner remains a
coveted and challenging goal in biology. We present a new aptamer-based proteomic …

Although plasma proteins have important roles in biological processes and are the direct
targets of many drugs, the genetic factors that control inter-individual variation in plasma …

Vascular endothelial growth factor (VEGF) has been implicated in the pathological induction
of new blood vessel growth in a variety of proliferative disorders. Using the SELEX process (…

We have identified a group of DNA molecules that bind to platelet-derived growth factor (PDGF)-AB
with subnanomolar affinity from a randomized DNA library using in vitro selection. …

Limited chemical diversity of nucleic acid libraries has long been suspected to be a major
constraining factor in the overall success of SELEX (Systematic Evolution of Ligands by …

VEGF 165 , the most abundant isoform in man, is an angiogenic cytokine that also regulates
vascular permeability. Its function in the renal glomerulus, where it is expressed in visceral …

Revised Manuscript Received May 17, 1994® abstract: The proliferation of new blood vessels
(angiogenesis) is a process that accompanies many pathological conditions including …

Mesangial cell proliferation and matrix accumulation, driven by platelet-derived growth factor
(PDGF), contribute to many progressive renal diseases. In a novel approach to antagonize …