Mounting an immune response is an energy-consuming process. Activating immune functions
requires the synthesis of many new molecules and the undertaking of numerous cellular …

10.7554/eLife.50414.001 Macrophage-mediated phagocytosis and cytokine production
represent the front lines of resistance to bacterial invaders. A key feature of this pro-inflammatory …

The immune response is an energy‐demanding process that must be coordinated with systemic
metabolic changes redirecting nutrients from stores to the immune system. Although this …

Immunotherapy emerges as a fundamental approach in cancer treatment. Up to date, the
efficacy of numerous different immunotherapies has been evaluated. The use of …

The idea of using killed microorganisms or their parts for a stimulation of immunity in the
cancer immunotherapy is very old, but the question of interactions and binding of these …

Activation of immune cells requires the remodeling of cell metabolism in order to support
immune function. We study these metabolic changes through the infection of Drosophila larvae …

In response to invading pathogens, macrophages metabolically polarize toward Hif1α-induced
aerobic glycolysis, requiring increased supply of nutrients. Here, we show that in order to …

… student Pavla Nedbalová who gave me great guidance and instruction. In addition, I would
like to thank all the members of the laboratory for the great and friendly cooperation and to …

… We are grateful to Tomaš Dolezal and Pavla Nedbalová for access to and sharing
experience with the parasitoid wasp infection model at the University of South Bohemia (Ceske …

Bacteria of the genus Massilia often colonize extreme ecosystems, however, a detailed
study of the massilias from the Antarctic environment has not yet been performed. Here, sixty-four …