Multiple roles for glyceraldehyde-3-phosphate dehydrogenase (GAPDH) have been recently
appreciated. In addition to the cytoplasm where the majority of GAPDH is located under the …

Besides its role in glycolysis, glyceraldehyde-3-phosphate dehydrogenase (GAPDH) initiates
a cell death cascade 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 . Diverse apoptotic stimuli activate inducible …

Tau becomes characteristically altered both functionally and structurally in several
neurodegenerative diseases now collectively called tauopathies. Although increasing evidence …

The tau proteins belong to the family of microtubule-associated proteins. They are mainly
expressed in neurons where they play major regulatory roles in the organization and integrity …

The polyglutamine expansion of huntingtin (mHTT) causes Huntington disease (HD) and
neurodegeneration, but the mechanisms remain unclear. Here, we found that mHtt promotes …

The protein mutated in Huntington disease (HD), mutant huntingtin (mHtt), is expressed
throughout the brain and body. However, the pathology of HD is characterized by early and …

L-DOPA–induced dyskinesia, the rate-limiting side effect in the therapy of Parkinson's
disease, is mediated by activation of mammalian target of rapamycin (mTOR) signaling in the …

In patients with Huntington’s disease (HD), the protein huntingtin (Htt) has an expanded
polyglutamine (poly-Q) tract. HD results in early loss of medium spiny neurons in the striatum, …

Huntington disease (HD) is caused by an expansion mutation of the N-terminal polyglutamine
of huntingtin (mHTT). mHTT is ubiquitously present, but it induces noticeable damage to …

The neurotrophin receptor p75 NTR has been implicated in mediating neuronal apoptosis
after injury to the CNS. Despite its frequent induction in pathologic states, there is limited …