FMRP targets distinct mRNA sequence elements to regulate protein expression
Fragile X syndrome (FXS) is a multi-organ disease that leads to mental retardation, macro-orchidism
in males and premature ovarian insufficiency in female carriers. FXS is also a …
in males and premature ovarian insufficiency in female carriers. FXS is also a …
[PDF][PDF] Integrative regulatory mapping indicates that the RNA-binding protein HuR couples pre-mRNA processing and mRNA stability
RNA-binding proteins coordinate the fates of multiple RNAs, but the principles underlying
these global interactions remain poorly understood. We elucidated regulatory mechanisms of …
these global interactions remain poorly understood. We elucidated regulatory mechanisms of …
A viral microRNA functions as an orthologue of cellular miR-155
E Gottwein, N Mukherjee, C Sachse, C Frenzel… - Nature, 2007 - nature.com
All metazoan eukaryotes express microRNAs (miRNAs), roughly 22-nucleotide regulatory
RNAs that can repress the expression of messenger RNAs bearing complementary …
RNAs that can repress the expression of messenger RNAs bearing complementary …
Detecting actively translated open reading frames in ribosome profiling data
RNA-sequencing protocols can quantify gene expression regulation from transcription to
protein synthesis. Ribosome profiling (Ribo-seq) maps the positions of translating ribosomes …
protein synthesis. Ribosome profiling (Ribo-seq) maps the positions of translating ribosomes …
[HTML][HTML] PARalyzer: definition of RNA binding sites from PAR-CLIP short-read sequence data
DL Corcoran, S Georgiev, N Mukherjee, E Gottwein… - Genome biology, 2011 - Springer
Crosslinking and immunoprecipitation (CLIP) protocols have made it possible to identify
transcriptome-wide RNA-protein interaction sites. In particular, PAR-CLIP utilizes a …
transcriptome-wide RNA-protein interaction sites. In particular, PAR-CLIP utilizes a …
[PDF][PDF] Viral microRNA targetome of KSHV-infected primary effusion lymphoma cell lines
Primary effusion lymphoma (PEL) is caused by Kaposi's sarcoma-associated herpesvirus (KSHV)
and frequently also harbors Epstein-Barr virus (EBV). The expression of KSHV- and …
and frequently also harbors Epstein-Barr virus (EBV). The expression of KSHV- and …
Integrative classification of human coding and noncoding genes through RNA metabolism profiles
N Mukherjee, L Calviello, A Hirsekorn… - Nature structural & …, 2017 - nature.com
Pervasive transcription of the human genome results in a heterogeneous mix of coding
RNAs and long noncoding RNAs (lncRNAs). Only a small fraction of lncRNAs have …
RNAs and long noncoding RNAs (lncRNAs). Only a small fraction of lncRNAs have …
Ribonomic Analysis of Human Pum1 Reveals cis-trans Conservation across Species despite Evolution of Diverse mRNA Target Sets
AR Morris, N Mukherjee, JD Keene - Molecular and cellular biology, 2008 - Taylor & Francis
PUF family proteins are among the best-characterized regulatory RNA-binding proteins in
nonmammalian species, but relatively little is known about mRNA targets or functions of …
nonmammalian species, but relatively little is known about mRNA targets or functions of …
[HTML][HTML] Global target mRNA specification and regulation by the RNA-binding protein ZFP36
N Mukherjee, NC Jacobs, M Hafner, EA Kennington… - Genome biology, 2014 - Springer
Background ZFP36, also known as tristetraprolin or TTP, and ELAVL1, also known as HuR,
are two disease-relevant RNA-binding proteins (RBPs) that both interact with AU-rich …
are two disease-relevant RNA-binding proteins (RBPs) that both interact with AU-rich …
Systematic analysis of posttranscriptional gene expression
AR Morris, N Mukherjee… - … Reviews: Systems Biology …, 2010 - Wiley Online Library
Recent systems studies of gene expression have begun to dissect the layers of regulation
that underlie the eukaryotic transcriptome, the combined consequence of transcriptional and …
that underlie the eukaryotic transcriptome, the combined consequence of transcriptional and …