[HTML][HTML] MNRR1 is a driver of ovarian cancer progression
H Chehade, N Purandare, A Fox, N Adzibolosu… - Translational …, 2023 - Elsevier
Cancer progression requires the acquisition of mechanisms that support proliferative
potential and metastatic capacity. MNRR1 (also CHCHD2, PARK22, AAG10) is a bi-organellar …
potential and metastatic capacity. MNRR1 (also CHCHD2, PARK22, AAG10) is a bi-organellar …
[HTML][HTML] Mitochondrial Oxidative Phosphorylation in Viral Infections
N Purandare, E Ghosalkar, LI Grossman, S Aras - Viruses, 2023 - mdpi.com
Mitochondria have been identified as the “powerhouse” of the cell, generating the cellular
energy, ATP, for almost seven decades. Research over time has uncovered a multifaceted role …
energy, ATP, for almost seven decades. Research over time has uncovered a multifaceted role …
Mitochondrial Nuclear Retrograde Regulator 1 (MNRR1) rescues the cellular phenotype of MELAS by inducing homeostatic mechanisms
MNRR1 (CHCHD2) is a bi-organellar regulator of mitochondrial function that directly activates
cytochrome c oxidase in the mitochondria and functions in the nucleus as a transcriptional …
cytochrome c oxidase in the mitochondria and functions in the nucleus as a transcriptional …
[HTML][HTML] The cellular stress proteins CHCHD10 and MNRR1 (CHCHD2): Partners in mitochondrial and nuclear function and dysfunction
N Purandare, M Somayajulu, M Hüttemann… - Journal of Biological …, 2018 - ASBMB
Coiled-coil-helix-coiled-coil-helix domain–containing 10 (CHCHD10) and CHCHD2 (MNRR1)
are homologous proteins with 58% sequence identity and belong to the twin CX 9 C …
are homologous proteins with 58% sequence identity and belong to the twin CX 9 C …
[PDF][PDF] Lipopolysaccharide induces placental mitochondrial dysfunction in murine and human systems by reducing MNRR1 levels via a TLR4-independent pathway
Mitochondria play a key role in placental growth and development, and mitochondrial
dysfunction is associated with inflammation in pregnancy pathologies. However, the mechanisms …
dysfunction is associated with inflammation in pregnancy pathologies. However, the mechanisms …
[HTML][HTML] MNRR1, a biorganellar regulator of mitochondria
LI Grossman, N Purandare, R Arshad… - … medicine and cellular …, 2017 - hindawi.com
The central role of energy metabolism in cellular activities is becoming widely recognized.
However, there are many gaps in our knowledge of the mechanisms by which mitochondria …
However, there are many gaps in our knowledge of the mechanisms by which mitochondria …
[HTML][HTML] Contemporary Antiretroviral Therapy Dysregulates Iron Transport and Augments Mitochondrial Dysfunction in HIV-Infected Human Microglia and Neural …
…, D Alvarez-Carbonell, N Purandare… - International Journal of …, 2023 - mdpi.com
HIV-associated cognitive dysfunction during combination antiretroviral therapy (cART)
involves mitochondrial dysfunction, but the impact of contemporary cART on chronic metabolic …
involves mitochondrial dysfunction, but the impact of contemporary cART on chronic metabolic …
[HTML][HTML] Abl2 kinase phosphorylates Bi-organellar regulator MNRR1 in mitochondria, stimulating respiration
S Aras, H Arrabi, N Purandare, M Hüttemann… - … et Biophysica Acta (BBA …, 2017 - Elsevier
We previously showed that MNRR1 (Mitochondrial Nuclear Retrograde Regulator 1, also
CHCHD2) functions in two subcellular compartments, displaying a different function in each. In …
CHCHD2) functions in two subcellular compartments, displaying a different function in each. In …
Molecular mechanisms regulating lysophosphatidylcholine acyltransferase 1 (LPCAT1) in human pregnancy
N Purandare, P Minchella, M Somayajulu, KJ Kramer… - Placenta, 2021 - Elsevier
Introduction Lysophosphatidylcholine Acyltransferase 1 (LPCAT1) is necessary for surfactant
production in fetal lungs. Mechanisms responsible for its regulation during gestation …
production in fetal lungs. Mechanisms responsible for its regulation during gestation …
Tris-heteroleptic ruthenium (II) polypyridyl complexes: synthesis, structural characterization, photophysical, electrochemistry and biological properties
SS Bhat, AS Kumbhar, N Purandare, A Khan… - Journal of Inorganic …, 2020 - Elsevier
Three water-soluble tris-heteroleptic ruthenium(II) polypyridyl complexes [Ru(bpy)(phen)(bpg)]
2+ (1), [Ru(bpy)(dppz)(bpg)] 2+ (2), and [Ru(phen)(dppz)(bpg)] 2+ (3) (where bpy = 2,2′-…
2+ (1), [Ru(bpy)(dppz)(bpg)] 2+ (2), and [Ru(phen)(dppz)(bpg)] 2+ (3) (where bpy = 2,2′-…