User profiles for Negar Khazan

Negar Khazan

Researcher at University of Rochester
Verified email at urmc.Rochester.edu
Cited by 102

[HTML][HTML] A Multi-Center Clinical Study to Harvest and Characterize Circulating Tumor Cells from Patients with Metastatic Breast Cancer Using the Parsortix® PC1 …

…, JE Lang, JD Khoury, MF Press, KK Kim, N Khazan… - Cancers, 2022 - mdpi.com
Simple Summary There is a great need to understand the cellular and molecular characteristics
of cancer when access to the tumor is limited. Circulating tumor cells (CTCs) captured …

[HTML][HTML] Role of trypsin and protease-activated receptor-2 in ovarian cancer

KK Kim, R Turner, N Khazan, A Kodza, A Jones… - PLoS …, 2020 - journals.plos.org
Proteases have been implicated in the tumorigenesis and aggressiveness of a variety of
cancer types. In fact, proteases have proven to be very clinically useful as tumor biomarkers in …

HE4 overexpression by ovarian cancer promotes a suppressive tumor immune microenvironment and enhanced tumor and macrophage PD-L1 expression

…, A Urh, N Yano, KK Kim, N Khazan… - The Journal of …, 2021 - journals.aai.org
Ovarian cancer is a highly fatal malignancy characterized by early chemotherapy responsiveness
but the eventual development of resistance. Immune targeting therapies are changing …

Identification of a Vitamin-D Receptor Antagonist, MeTC7, which Inhibits the Growth of Xenograft and Transgenic Tumors In Vivo

N Khazan, KK Kim, JN Hansen, NA Singh… - Journal of medicinal …, 2022 - ACS Publications
Vitamin-D receptor (VDR) mRNA is overexpressed in neuroblastoma and carcinomas of
lung, pancreas, and ovaries and predicts poor prognoses. VDR antagonists may be able to …

[HTML][HTML] Vitamin D Receptor Antagonist MeTC7 Inhibits PD-L1

N Khazan, ER Quarato, NA Singh, CWA Snyder… - Cancers, 2023 - mdpi.com
Simple Summary Programmed death-ligand 1 (PD-L1) enables immune evasion of tumors.
Antibodies targeting PD-L1/PD-1 exhibit durable responses in eligible patients. However, …

[HTML][HTML] Analytical performance of the FDA-cleared Parsortix® PC1 system

…, SG Peters, M De Piano, M Teo, N Khazan… - Journal of Circulating …, 2023 - ncbi.nlm.nih.gov
Methods: System performance was determined using K 2-EDTA blood samples collected
from self-declared healthy female volunteers (HVs) and MBC patients spiked with prelabeled …

[HTML][HTML] Development of potent forchlorfenuron analogs and their cytotoxic effect in cancer cell lines

KK Kim, RK Singh, N Khazan, A Kodza, NA Singh… - Scientific Reports, 2020 - nature.com
Forchlorfenuron (FCF) is a synthetic plant cytokinin widely used in agriculture to promote fruit
size, that paradoxically inhibits proliferation, migration, and invasion in human cancer cell …

[HTML][HTML] Forchlorfenuron-Induced Mitochondrial Respiration Inhibition and Metabolic Shifts in Endometrial Cancer

K Kim, N Khazan, RB Rowswell-Turner, RK Singh… - Cancers, 2024 - mdpi.com
Simple Summary Our research focuses on the molecular mechanism of forchlorfenuron (FCF),
a plant growth regulator widely used in agriculture to enhance fruit size and quality, and …

[HTML][HTML] Malignancy assessment using gene identification in captured cells algorithm for the prediction of malignancy in women with a pelvic mass

RG Moore, N Khazan, MA Coulter, R Singh… - Obstetrics & …, 2022 - journals.lww.com
OBJECTIVE: To evaluate the detection of malignancy in women with a pelvic mass by using
multiplexed gene expression analysis of cells captured from peripheral blood. METHODS: …

[HTML][HTML] Novel small molecule mek inhibitor urml-3881 enhances cisplatin sensitivity in clear cell ovarian cancer

…, JA Rutishauser, KK Kim, N Khazan… - Translational …, 2019 - Elsevier
Advanced clear cell ovarian cancer (CCOC) is a highly fatal malignancy with a scarcity of
effective treatment options. CCOC is inherently chemotherapy resistance, but the exact …