User profiles for Negar Khazan
Negar KhazanResearcher at University of Rochester Verified email at urmc.Rochester.edu Cited by 102 |
[HTML][HTML] A Multi-Center Clinical Study to Harvest and Characterize Circulating Tumor Cells from Patients with Metastatic Breast Cancer Using the Parsortix® PC1 …
Simple Summary There is a great need to understand the cellular and molecular characteristics
of cancer when access to the tumor is limited. Circulating tumor cells (CTCs) captured …
of cancer when access to the tumor is limited. Circulating tumor cells (CTCs) captured …
[HTML][HTML] Role of trypsin and protease-activated receptor-2 in ovarian cancer
KK Kim, R Turner, N Khazan, A Kodza, A Jones… - PLoS …, 2020 - journals.plos.org
Proteases have been implicated in the tumorigenesis and aggressiveness of a variety of
cancer types. In fact, proteases have proven to be very clinically useful as tumor biomarkers in …
cancer types. In fact, proteases have proven to be very clinically useful as tumor biomarkers in …
HE4 overexpression by ovarian cancer promotes a suppressive tumor immune microenvironment and enhanced tumor and macrophage PD-L1 expression
Ovarian cancer is a highly fatal malignancy characterized by early chemotherapy responsiveness
but the eventual development of resistance. Immune targeting therapies are changing …
but the eventual development of resistance. Immune targeting therapies are changing …
Identification of a Vitamin-D Receptor Antagonist, MeTC7, which Inhibits the Growth of Xenograft and Transgenic Tumors In Vivo
N Khazan, KK Kim, JN Hansen, NA Singh… - Journal of medicinal …, 2022 - ACS Publications
Vitamin-D receptor (VDR) mRNA is overexpressed in neuroblastoma and carcinomas of
lung, pancreas, and ovaries and predicts poor prognoses. VDR antagonists may be able to …
lung, pancreas, and ovaries and predicts poor prognoses. VDR antagonists may be able to …
[HTML][HTML] Vitamin D Receptor Antagonist MeTC7 Inhibits PD-L1
N Khazan, ER Quarato, NA Singh, CWA Snyder… - Cancers, 2023 - mdpi.com
Simple Summary Programmed death-ligand 1 (PD-L1) enables immune evasion of tumors.
Antibodies targeting PD-L1/PD-1 exhibit durable responses in eligible patients. However, …
Antibodies targeting PD-L1/PD-1 exhibit durable responses in eligible patients. However, …
[HTML][HTML] Analytical performance of the FDA-cleared Parsortix® PC1 system
…, SG Peters, M De Piano, M Teo, N Khazan… - Journal of Circulating …, 2023 - ncbi.nlm.nih.gov
Methods: System performance was determined using K 2-EDTA blood samples collected
from self-declared healthy female volunteers (HVs) and MBC patients spiked with prelabeled …
from self-declared healthy female volunteers (HVs) and MBC patients spiked with prelabeled …
[HTML][HTML] Development of potent forchlorfenuron analogs and their cytotoxic effect in cancer cell lines
Forchlorfenuron (FCF) is a synthetic plant cytokinin widely used in agriculture to promote fruit
size, that paradoxically inhibits proliferation, migration, and invasion in human cancer cell …
size, that paradoxically inhibits proliferation, migration, and invasion in human cancer cell …
[HTML][HTML] Forchlorfenuron-Induced Mitochondrial Respiration Inhibition and Metabolic Shifts in Endometrial Cancer
K Kim, N Khazan, RB Rowswell-Turner, RK Singh… - Cancers, 2024 - mdpi.com
Simple Summary Our research focuses on the molecular mechanism of forchlorfenuron (FCF),
a plant growth regulator widely used in agriculture to enhance fruit size and quality, and …
a plant growth regulator widely used in agriculture to enhance fruit size and quality, and …
[HTML][HTML] Malignancy assessment using gene identification in captured cells algorithm for the prediction of malignancy in women with a pelvic mass
RG Moore, N Khazan, MA Coulter, R Singh… - Obstetrics & …, 2022 - journals.lww.com
OBJECTIVE: To evaluate the detection of malignancy in women with a pelvic mass by using
multiplexed gene expression analysis of cells captured from peripheral blood. METHODS: …
multiplexed gene expression analysis of cells captured from peripheral blood. METHODS: …
[HTML][HTML] Novel small molecule mek inhibitor urml-3881 enhances cisplatin sensitivity in clear cell ovarian cancer
…, JA Rutishauser, KK Kim, N Khazan… - Translational …, 2019 - Elsevier
Advanced clear cell ovarian cancer (CCOC) is a highly fatal malignancy with a scarcity of
effective treatment options. CCOC is inherently chemotherapy resistance, but the exact …
effective treatment options. CCOC is inherently chemotherapy resistance, but the exact …