Surface Proteomics Reveals CD72 as a Target for In Vitro–Evolved Nanobody-Based CAR-T Cells in KMT2A/MLL1-Rearranged B-ALL
Patients with MLLr B-ALL have poor prognoses despite recent immunotherapy advances.
Here, surface proteomics identifies CD72 as being enriched on MLLr B-ALL but also widely …
Here, surface proteomics identifies CD72 as being enriched on MLLr B-ALL but also widely …
Structure–Activity Relationship of Lower Chlorinated Biphenyls and Their Human-Relevant Metabolites for Astrocyte Toxicity
N Paranjape, LE Dean, A Martinez… - Chemical research in …, 2023 - ACS Publications
Exposure to polychlorinated biphenyls (PCBs) is associated with developmental neurotoxicity
and neurodegenerative disorders; however, the underlying mechanisms of pathogenesis …
and neurodegenerative disorders; however, the underlying mechanisms of pathogenesis …
Outcomes and adverse effects of baricitinib versus tocilizumab in the management of severe COVID-19
JH Peterson, NS Paranjape, N Grundlingh… - Critical Care …, 2023 - journals.lww.com
Objectives: The National Institutes of Health and Infectious Diseases Society of America
guidelines recommend tocilizumab or baricitinib in the management of severe COVID-19. …
guidelines recommend tocilizumab or baricitinib in the management of severe COVID-19. …
[HTML][HTML] A CRISPR-engineered isogenic model of the 22q11. 2 AB syndromic deletion
N Paranjape, YHT Lin, Q Flores-Ramirez, V Sarin… - Scientific reports, 2023 - nature.com
22q11.2 deletion syndrome, associated with congenital and neuropsychiatric anomalies, is
the most common copy number variant (CNV)-associated syndrome. Patient-derived, …
the most common copy number variant (CNV)-associated syndrome. Patient-derived, …
[HTML][HTML] Swertisin an anti-diabetic compound facilitate islet neogenesis from pancreatic stem/progenitor cells via p-38 MAP kinase-SMAD pathway: an in-vitro and in …
Transplanting islets serves best option for restoring lost beta cell mass and function. Small
bio-chemical agents do have the potential to generate new islets mass, however lack of …
bio-chemical agents do have the potential to generate new islets mass, however lack of …
Thalamocortical organoids enable in vitro modeling of 22q11. 2 microdeletion associated with neuropsychiatric disorders
Thalamic dysfunction has been implicated in multiple psychiatric disorders. We sought to
study the mechanisms by which abnormalities emerge in the context of the 22q11.2 …
study the mechanisms by which abnormalities emerge in the context of the 22q11.2 …
[HTML][HTML] Early use of remdesivir in patients hospitalized with COVID-19 improves clinical outcomes: a retrospective observational study
N Paranjape, M Husain, J Priestley… - Infectious Diseases in …, 2021 - journals.lww.com
Background Remdesivir treatment, like most antiviral drugs, is likely to be most effective
when used early in the course of coronavirus disease 2019 (COVID-19). Optimal timing of …
when used early in the course of coronavirus disease 2019 (COVID-19). Optimal timing of …
[HTML][HTML] Development and validation of a predictive model for critical illness in adult patients requiring hospitalization for COVID-19
Background Identifying factors that can predict severe disease in patients needing hospitalization
for COVID-19 is crucial for early recognition of patients at greatest risk. Objective (1) …
for COVID-19 is crucial for early recognition of patients at greatest risk. Objective (1) …
DNA sequence templates adjacent nucleosome and ORC sites at gene amplification origins in Drosophila
Eukaryotic origins of DNA replication are bound by the origin recognition complex (ORC),
which scaffolds assembly of a pre-replicative complex (pre-RC) that is then activated to initiate …
which scaffolds assembly of a pre-replicative complex (pre-RC) that is then activated to initiate …
[HTML][HTML] Paragonimiasis presenting as an acute hemorrhagic stroke
N Paranjape, V Nunez, D Dicks - IDCases, 2021 - Elsevier
Cerebral paragonimiasis is rare and is usually seen in younger patients. This is a case of a
19-year-old male presenting as a hemorrhagic stroke with headache and blurred vision. He …
19-year-old male presenting as a hemorrhagic stroke with headache and blurred vision. He …