Melting of iron at the physical conditions of the Earth's core

JH Nguyen, NC Holmes - Nature, 2004 - nature.com
Seismological data can yield physical properties of the Earth's core, such as its size and
seismic anisotropy 1 , 2 , 3 . A well-constrained iron phase diagram, however, is essential to …

[HTML][HTML] Formicamycins, antibacterial polyketides produced by Streptomyces formicae isolated from African Tetraponera plant-ants

Z Qin, JT Munnoch, R Devine, NA Holmes… - Chemical …, 2017 - pubs.rsc.org
We report a new Streptomyces species named S. formicae that was isolated from the African
fungus-growing plant-ant Tetraponera penzigi and show that it produces novel pentacyclic …

Coiled-coil protein Scy is a key component of a multiprotein assembly controlling polarized growth in Streptomyces

NA Holmes, J Walshaw, RM Leggett… - Proceedings of the …, 2013 - National Acad Sciences
Polarized growth in eukaryotes requires polar multiprotein complexes. Here, we establish
that selection and maintenance of cell polarity for growth also requires a dedicated …

Streptomyces Endophytes Promote Host Health and Enhance Growth across Plant Species

…, J Rassbach, SFD Batey, NA Holmes… - Applied and …, 2020 - Am Soc Microbiol
Streptomyces bacteria are ubiquitous in soils and are well known for producing secondary
metabolites, including antimicrobials. Increasingly, they are being isolated from plant roots, …

Structural basis of dual activation of cell division by the actinobacterial transcription factors WhiA and WhiB

M Lilic, NA Holmes, MJ Bush, AK Marti… - Proceedings of the …, 2023 - National Acad Sciences
Studies of transcriptional initiation in different bacterial clades reveal diverse molecular
mechanisms regulating this first step in gene expression. The WhiA and WhiB factors are both …

[HTML][HTML] Chemical warfare between leafcutter ant symbionts and a co-evolved pathogen

D Heine, NA Holmes, SF Worsley, ACA Santos… - Nature …, 2018 - nature.com
Acromyrmex leafcutter ants form a mutually beneficial symbiosis with the fungus Leucoagaricus
gongylophorus and with Pseudonocardia bacteria. Both are vertically transmitted and …

[PDF][PDF] c-di-GMP arms an anti-σ to control progression of multicellular differentiation in Streptomyces

…, MJ Bush, MJ Bibb, G Chandra, NA Holmes… - Molecular Cell, 2020 - cell.com
Streptomyces are our primary source of antibiotics, produced concomitantly with the transition
from vegetative growth to sporulation in a complex developmental life cycle. We previously …

[HTML][HTML] Genome analysis of two Pseudonocardia phylotypes associated with Acromyrmex leafcutter ants reveals their biosynthetic potential

NA Holmes, TM Innocent, D Heine… - Frontiers in …, 2016 - frontiersin.org
The attine ants of South and Central America are ancient farmers, having evolved a symbiosis
with a fungal food crop >50 million years ago. The most evolutionarily derived attines are …

The MtrAB two-component system controls antibiotic production in Streptomyces coelicolor A3(2)

NF Som, D Heine, N Holmes, F Knowles… - …, 2017 - microbiologyresearch.org
MtrAB is a highly conserved two-component system implicated in the regulation of cell division
in the Actinobacteria. It coordinates DNA replication with cell division in the unicellular …

[HTML][HTML] The Conserved Actinobacterial Two-Component System MtrAB Coordinates Chloramphenicol Production with Sporulation in Streptomyces venezuelae …

NF Som, D Heine, NA Holmes, JT Munnoch… - Frontiers in …, 2017 - frontiersin.org
Streptomyces bacteria make numerous secondary metabolites, including half of all known
antibiotics. Production of antibiotics is usually coordinated with the onset of sporulation but the …