Chromatin modifying activities inherent to polycomb repressive complexes PRC1 and PRC2
play an essential role in gene regulation, cellular differentiation, and development. However…

Precise control of gene expression is fundamental to cell function and development. Although
ultimately gene expression relies on DNA-binding transcription factors to guide the activity …

10.7554/eLife.00205.001 CpG islands (CGIs) are associated with most mammalian gene
promoters. A subset of CGIs act as polycomb response elements (PREs) and are recognized …

The mechanisms by which the major Polycomb group (PcG) complexes PRC1 and PRC2
are recruited to target sites in vertebrate cells are not well understood. Building on recent …

In higher eukaryotes, up to 70% of genes have high levels of nonmethylated cytosine/guanine
base pairs (CpGs) surrounding promoters and gene regulatory units. These features, …

Polycomb group proteins are transcriptional repressors that are essential for normal gene
regulation during development. Recent studies suggest that Polycomb repressive complexes (…

… In this study, Blackledge et al. generate a conditional catalytic point mutant system to test
the contribution of PRC1 catalytic activity to the Polycomb repressive system. They reveal that …

Vertebrate DNA can be chemically modified by methylation of the 5 position of the cytosine
base in the context of CpG dinucleotides. This modification creates a binding site for MBD (…

The Polycomb system modifies chromatin and plays an essential role in repressing gene
expression to control normal mammalian development. However, the components and …

10.7554/eLife.00348.001 Two-thirds of gene promoters in mammals are associated with
regions of non-methylated DNA, called CpG islands (CGIs), which counteract the repressive …