Human genetics is now at a critical juncture. The molecular methods used successfully to
identify the genes underlying rare mendelian syndromes are failing to find the numerous …

The identification of the genetic basis of complex human diseases such as schizophrenia
and diabetes has proven difficult. In their Perspective, Risch and Merikangas propose that we …

Context Substantial resources are being devoted to identify candidate genes for complex
mental and behavioral disorders through inclusion of environmental exposures following the …

A primary goal of human genetics is to identify DNA sequence variants that influence
biomedical traits, particularly those related to the onset and progression of human disease. Over …

Objective. —To examine more closely the association between apolipoprotein E (APOE)
genotype and Alzheimer disease (AD) by age and sex in populations of various ethnic and …

Context Autism is considered the most heritable of neurodevelopmental disorders, mainly
because of the large difference in concordance rates between monozygotic and dizygotic twins…

The past two decades have witnessed an explosion in the identification, largely by positional
cloning, of genes associated with mendelian diseases. The roughly 1,200 genes that have …

In order to investigate linkage detection strategies for genetically complex traits, multilocus
models of inheritance need to be specified. Here, two types of multilocus model are described:…

Association studies with candidate genes have been widely used for the study of complex
diseases. However, this approach has been criticized because of non-replication of results …

Background A family history of premature coronary heart disease has long been thought to
be a risk factor for coronary heart disease. Using data from 26 years of follow-up of 21,004 …