Diabetes represents one of the most important global health problems because it is associated
with a large economic burden on the health systems of many countries. Whereas the …

Cases of pancreatitis have been described in connection with the use of exenatide (1), liraglutide
(2) and other glucagon-like peptide (GLP)-1 receptor agonists. From these findings, the …

Obesity is globally prevalent and highly heritable, but its underlying genetic factors remain
largely elusive. To identify genetic loci for obesity susceptibility, we examined associations …

Although in the past century mortality in West Germany decreased similarly as in other
Western nations, these changes were less pronounced in East Germany. 1, 2 After German …

Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic
outcomes, independent of overall adiposity. To increase our understanding of the genetic …

Context: To date, it is unclear which measure of obesity is the most appropriate for risk
stratification. Objective: The aim of the study was to compare the associations of various measures …

Concentrations of liver enzymes in plasma are widely used as indicators of liver disease.
We carried out a genome-wide association study in 61,089 individuals, identifying 42 loci …

Context: Measurement of IGF-I is a cornerstone in diagnosis and monitoring of GH-related
diseases, but considerable discrepancies exist between analytical methods. A recent …

Genome-wide association studies (GWAS) have identified >250 loci for body mass index (BMI),
implicating pathways related to neuronal biology. Most GWAS loci represent clusters of …

To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic
disease risk, we conducted a genome-wide association meta-analysis of body fat …