User profiles for Nelson Freimer
Nelson FreimerProfessor of Psychiatry, Ucla Verified email at mednet.ucla.edu Cited by 81327 |
Biological, clinical and population relevance of 95 loci for blood lipids
…, LC Groop, E Gonzalez, C Gieger, NB Freimer… - Nature, 2010 - nature.com
Plasma concentrations of total cholesterol, low-density lipoprotein cholesterol, high-density
lipoprotein cholesterol and triglycerides are among the most important risk factors for …
lipoprotein cholesterol and triglycerides are among the most important risk factors for …
Mapping genomic loci implicates genes and synaptic biology in schizophrenia
…, A Fiorentino, A Forstner, J Frank, NB Freimer… - Nature, 2022 - nature.com
Schizophrenia has a heritability of 60–80% 1 , much of which is attributable to common risk
alleles. Here, in a two-stage genome-wide association study of up to 76,755 individuals with …
alleles. Here, in a two-stage genome-wide association study of up to 76,755 individuals with …
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
…, AR Folsom, N Friedrich, NB Freimer… - Nature …, 2010 - nature.com
Obesity is globally prevalent and highly heritable, but its underlying genetic factors remain
largely elusive. To identify genetic loci for obesity susceptibility, we examined associations …
largely elusive. To identify genetic loci for obesity susceptibility, we examined associations …
Hundreds of variants clustered in genomic loci and biological pathways affect human height
Most common human traits and diseases have a polygenic pattern of inheritance: DNA
sequence variants at many genetic loci influence the phenotype. Genome-wide association (GWA…
sequence variants at many genetic loci influence the phenotype. Genome-wide association (GWA…
Variance component model to account for sample structure in genome-wide association studies
Although genome-wide association studies (GWASs) have identified numerous loci associated
with complex traits, imprecise modeling of the genetic relatedness within study samples …
with complex traits, imprecise modeling of the genetic relatedness within study samples …
Large recurrent microdeletions associated with schizophrenia
…, C Sabatti, NB Freimer… - nature, 2008 - nature.com
Reduced fecundity, associated with severe mental disorders 1 , places negative selection
pressure on risk alleles and may explain, in part, why common variants have not been found …
pressure on risk alleles and may explain, in part, why common variants have not been found …
Common variants conferring risk of schizophrenia
Schizophrenia is a complex disorder, caused by both genetic and environmental factors and
their interactions. Research on pathogenesis has traditionally focused on neurotransmitter …
their interactions. Research on pathogenesis has traditionally focused on neurotransmitter …
Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology
Bipolar disorder is a heritable mental illness with complex etiology. We performed a genome-wide
association study of 41,917 bipolar disorder cases and 371,549 controls of European …
association study of 41,917 bipolar disorder cases and 371,549 controls of European …
Genome-wide association study identifies eight loci associated with blood pressure
…, SM Schwartz, DS Siscovick, I Subirana, NB Freimer… - Nature …, 2009 - nature.com
Elevated blood pressure is a common, heritable cause of cardiovascular disease worldwide.
To date, identification of common genetic variants influencing blood pressure has proven …
To date, identification of common genetic variants influencing blood pressure has proven …
Genome-wide association study identifies 30 loci associated with bipolar disorder
…, TM Foroud, L Forty, J Frank, C Fraser, NB Freimer… - Nature …, 2019 - nature.com
Bipolar disorder is a highly heritable psychiatric disorder. We performed a genome-wide
association study (GWAS) including 20,352 cases and 31,358 controls of European descent, …
association study (GWAS) including 20,352 cases and 31,358 controls of European descent, …