User profiles for Nersisyan Lilit

Lilit Nersisyan

Armenian Bioinformatics Institute, Karolinska Institutet
Verified email at abi.am
Cited by 585

[HTML][HTML] Computel: computation of mean telomere length from whole-genome next-generation sequencing data

L Nersisyan, A Arakelyan - PLoS one, 2015 - journals.plos.org
Telomeres are the ends of eukaryotic chromosomes, consisting of consecutive short repeats
that protect chromosome ends from degradation. Telomeres shorten with each cell division, …

[HTML][HTML] Autoimmunity and autoinflammation: a systems view on signaling pathway dysregulation profiles

A Arakelyan, L Nersisyan, D Poghosyan… - PLoS …, 2017 - journals.plos.org
Introduction Autoinflammatory and autoimmune disorders are characterized by aberrant
changes in innate and adaptive immunity that may lead from an initial inflammatory state to an …

Genomic and transcriptomic heterogeneity of colorectal tumours arising in Lynch syndrome

…, S Siebert, C Grimm, L Nersisyan… - The Journal of …, 2017 - Wiley Online Library
Colorectal cancer (CRC) arising in Lynch syndrome (LS) comprises tumours with constitutional
mutations in DNA mismatch repair genes. There is still a lack of whole‐genome and …

[HTML][HTML] Structural basis for PoxtA-mediated resistance to phenicol and oxazolidinone antibiotics

…, S Huch, M Kasari, H Takada, L Nersisyan… - Nature …, 2022 - nature.com
PoxtA and OptrA are ATP binding cassette (ABC) proteins of the F subtype (ABCF). They
confer resistance to oxazolidinone and phenicol antibiotics, such as linezolid and …

[HTML][HTML] Telomere length maintenance and its transcriptional regulation in lynch syndrome and sporadic colorectal carcinoma

L Nersisyan, L Hopp, H Loeffler-Wirth, J Galle… - Frontiers in …, 2019 - frontiersin.org
Background: Activation of telomere maintenance mechanisms (TMMs) is a hallmark of most
cancers, and is required to prevent genome instability and to establish cellular immortality …

[HTML][HTML] Footprints of sepsis framed within community acquired pneumonia in the blood transcriptome

L Hopp, H Loeffler-Wirth, L Nersisyan… - Frontiers in …, 2018 - frontiersin.org
We analyzed the blood transcriptome of sepsis framed within community-acquired pneumonia
(CAP) and characterized its molecular and cellular heterogeneity in terms of functional …

[HTML][HTML] Transcriptomic maps of colorectal liver metastasis: machine learning of gene activation patterns and epigenetic trajectories in support of precision medicine

…, D Underwood, G Armen, A Arakelyan, L Nersisyan… - Cancers, 2023 - mdpi.com
Simple Summary Liver metastasis is a significant factor contributing to mortality associated
with colorectal cancer. Establishing the biological mechanisms of metastasis is crucial for …

KEGGParser: parsing and editing KEGG pathway maps in Matlab

A Arakelyan, L Nersisyan - Bioinformatics, 2013 - academic.oup.com
KEGG pathway database is a collection of manually drawn pathway maps accompanied
with KGML format files intended for use in automatic analysis. KGML files, however, do not …

[HTML][HTML] CyKEGGParser: tailoring KEGG pathways to fit into systems biology analysis workflows

L Nersisyan, R Samsonyan, A Arakelyan - F1000Research, 2014 - ncbi.nlm.nih.gov
The KEGG pathway database is a widely accepted source for biomolecular pathway maps.
In this paper we present the CyKEGGParser app (http://apps. cytoscape. org/apps/…

[PDF][PDF] Improved computational analysis of ribosome dynamics from 5′ P degradome data using fivepseq

L Nersisyan, M Ropat… - NAR Genomics and …, 2020 - academic.oup.com
In eukaryotes, 5′–3′ co-translation degradation machinery follows the last translating
ribosome providing an in vivo footprint of its position. Thus, 5′ monophosphorylated (5′P) …