User profiles for Nese Direk

Nese Direk, MD, PhD

Department of Psychiatry, Istanbul University, Istanbul
Verified email at istanbul.edu.tr
Cited by 8413

[PDF][PDF] Psychiatric epidemiology in Turkey: main advances in recent studies and future directions.

T Binbay, N Direk, T Aker, Y Akvardar… - Turk Psikiyatri …, 2014 - academia.edu
Objective: To overview and evaluate the main findings, methodological shortcomings, and
time trends of the recent psychiatric epidemiology studies in Turkey, as well as to provide …

Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

…, IJ Deary, F Degenhardt, EM Derks, N Direk… - Nature …, 2018 - nature.com
Major depressive disorder (MDD) is a common illness accompanied by considerable
morbidity, mortality, costs, and heightened risk of suicide. We conducted a genome-wide …

Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses

…, SR Cox, G Davies, OSP Davis, J Ding, N Direk… - Nature …, 2016 - nature.com
Very few genetic variants have been associated with depression and neuroticism, likely
because of limitations on sample size in previous studies. Subjective well-being, a phenotype …

24‐hour activity rhythm and sleep disturbances in depression and anxiety: A population‐based study of middle‐aged and older persons

AI Luik, LA Zuurbier, N Direk, A Hofman… - Depression and …, 2015 - Wiley Online Library
Background Disturbed circadian rhythms have been associated with depression and anxiety,
but it is unclear if disturbances in the 24‐hr activity rhythm and sleep are independently …

Meta-analysis of genome-wide association studies of anxiety disorders

…, A Teumer, Y Milaneschi, JJ Hottenga, N Direk… - Molecular …, 2016 - nature.com
Anxiety disorders (ADs), namely generalized AD, panic disorder and phobias, are common,
etiologically complex conditions with a partially genetic basis. Despite differing on diagnostic …

[PDF][PDF] Türkiye'de psikiyatrik epidemiyoloji: yakın zamanlı araştırmalarda temel bulgular ve gelecek için öneriler

T Binbay, N Direk, T Aker, Y Akvardar… - Turk Psikiyatri …, 2014 - researchgate.net
Amaç: Son yıllarda Türkiye’de psikiyatri alanında yapılmış epidemiyolojik araştırmalarda
öne çıkan bulguların, eksikliklerin ve ayrıca ilgili araştırma alanlarında gelecekte neler …

The genetic architecture of depression in individuals of East Asian ancestry: a genome-wide association study

…, IJ Deary, F Degenhardt, EM Derks, N Direk… - JAMA …, 2021 - jamanetwork.com
Importance Most previous genome-wide association studies (GWAS) of depression have used
data from individuals of European descent. This limits the understanding of the underlying …

[HTML][HTML] Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits

…, M Chittani, S Coggeshall, T Corre, N Direk… - Nature …, 2017 - nature.com
Few genome-wide association studies (GWAS) account for environmental exposures, like
smoking, potentially impacting the overall trait variance when investigating the genetic …

Major depressive disorder working group of the psychiatric genomics consortium

…, G Davies, F Degenhardt, EM Derks, N Direk… - Nat. Commun, 2020 - comm.ku.dk
A phenome-wide association and Mendelian Randomisation study of polygenic risk for
depression in UK Biobank - Ethnographic studies in innovative learning contexts Topic …

[HTML][HTML] Genome Wide Association Identifies Common Variants at the SERPINA6/SERPINA1 Locus Influencing Plasma Cortisol and Corticosteroid Binding Globulin

JL Bolton, C Hayward, N Direk, JG Lewis… - PLoS …, 2014 - journals.plos.org
Variation in plasma levels of cortisol, an essential hormone in the stress response, is
associated in population-based studies with cardio-metabolic, inflammatory and neuro-cognitive …