Hexokinase 2 is a key mediator of aerobic glycolysis and promotes tumor growth in human glioblastoma multiforme
…, S Agnihotri, J Micallef, J Mukherjee, N Sabha… - Journal of Experimental …, 2011 - rupress.org
Proliferating embryonic and cancer cells preferentially use aerobic glycolysis to support
growth, a metabolic alteration commonly referred to as the “Warburg effect.” Here, we show that …
growth, a metabolic alteration commonly referred to as the “Warburg effect.” Here, we show that …
Frequent ATRX mutations and loss of expression in adult diffuse astrocytic tumors carrying IDH1/IDH2 and TP53 mutations
XY Liu, N Gerges, A Korshunov, N Sabha… - Acta …, 2012 - Springer
Gliomas are the most common primary brain tumors in children and adults. We recently
identified frequent alterations in chromatin remodelling pathways including recurrent mutations …
identified frequent alterations in chromatin remodelling pathways including recurrent mutations …
Study of the biodistribution of fluorescein in glioma-infiltrated mouse brain and histopathological correlation of intraoperative findings in high-grade gliomas resected …
…, EM Hattab, K Burrell, P Rakopoulos, N Sabha… - Journal of …, 2015 - thejns.org
OBJECT Intravenous fluorescein sodium has been used during resection of high-grade
gliomas to help the surgeon visualize tumor margins. Several studies have reported improved …
gliomas to help the surgeon visualize tumor margins. Several studies have reported improved …
Brainstem blood brain barrier disruption using focused ultrasound: A demonstration of feasibility and enhanced doxorubicin delivery
S Alli, CA Figueiredo, B Golbourn, N Sabha… - Journal of controlled …, 2018 - Elsevier
Magnetic Resonance Image-guided Focused Ultrasound (MRgFUS) has been used to achieve
transient blood brain barrier (BBB) opening without tissue injury. Delivery of a targeted …
transient blood brain barrier (BBB) opening without tissue injury. Delivery of a targeted …
[HTML][HTML] PIK3C2B inhibition improves function and prolongs survival in myotubular myopathy animal models
N Sabha, JR Volpatti, H Gonorazky… - The Journal of …, 2016 - Am Soc Clin Investig
Myotubular myopathy (MTM) is a devastating pediatric neuromuscular disorder of phosphoinositide
(PIP) metabolism resulting from mutations of the PIP phosphatase MTM1 for which …
(PIP) metabolism resulting from mutations of the PIP phosphatase MTM1 for which …
[HTML][HTML] Uropathogenic E. coli infection provokes epigenetic downregulation of CDKN2A (p16INK4A) in uroepithelial cells
C Tolg, N Sabha, R Cortese, T Panchal, A Ahsan… - Laboratory …, 2011 - Elsevier
Host cell and bacterial factors determine severity and duration of infections. To allow for
bacteria pathogenicity and persistence, bacteria have developed mechanisms that modify …
bacteria pathogenicity and persistence, bacteria have developed mechanisms that modify …
ATM regulates 3-methylpurine-DNA glycosylase and promotes therapeutic resistance to alkylating agents
…, S Pajovic, C Ternamian, R Head, N Sabha… - Cancer discovery, 2014 - AACR
Alkylating agents are a first-line therapy for the treatment of several aggressive cancers,
including pediatric glioblastoma, a lethal tumor in children. Unfortunately, many tumors are …
including pediatric glioblastoma, a lethal tumor in children. Unfortunately, many tumors are …
Analysis of IDH mutation, 1p/19q deletion, and PTEN loss delineates prognosis in clinical low-grade diffuse gliomas
Background Grades II and III gliomas have unpredictable rates of progression, making
management decisions difficult. Currently, several clinical and radiological characteristics are …
management decisions difficult. Currently, several clinical and radiological characteristics are …
MRI-guided focused ultrasound enhances drug delivery in experimental diffuse intrinsic pontine glioma
J Ishida, S Alli, A Bondoc, B Golbourn, N Sabha… - Journal of controlled …, 2021 - Elsevier
Diffuse intrinsic pontine glioma (DIPG) is a surgically unresectable and devasting tumour in
children. To date, there are no effective chemotherapeutics despite a myriad of clinical trials. …
children. To date, there are no effective chemotherapeutics despite a myriad of clinical trials. …
High-grade glioma formation results from postnatal pten loss or mutant epidermal growth factor receptor expression in a transgenic mouse glioma model
…, L Clarke, DK Scheidenhelm, B Qian, A Tong, N Sabha… - Cancer research, 2006 - AACR
High-grade gliomas are devastating brain tumors associated with a mean survival of <50
weeks. Two of the most common genetic changes observed in these tumors are overexpression…
weeks. Two of the most common genetic changes observed in these tumors are overexpression…