Hexokinase 2 is a key mediator of aerobic glycolysis and promotes tumor growth in human glioblastoma multiforme

…, S Agnihotri, J Micallef, J Mukherjee, N Sabha… - Journal of Experimental …, 2011 - rupress.org
Proliferating embryonic and cancer cells preferentially use aerobic glycolysis to support
growth, a metabolic alteration commonly referred to as the “Warburg effect.” Here, we show that …

Frequent ATRX mutations and loss of expression in adult diffuse astrocytic tumors carrying IDH1/IDH2 and TP53 mutations

XY Liu, N Gerges, A Korshunov, N Sabha… - Acta …, 2012 - Springer
Gliomas are the most common primary brain tumors in children and adults. We recently
identified frequent alterations in chromatin remodelling pathways including recurrent mutations …

Study of the biodistribution of fluorescein in glioma-infiltrated mouse brain and histopathological correlation of intraoperative findings in high-grade gliomas resected …

…, EM Hattab, K Burrell, P Rakopoulos, N Sabha… - Journal of …, 2015 - thejns.org
OBJECT Intravenous fluorescein sodium has been used during resection of high-grade
gliomas to help the surgeon visualize tumor margins. Several studies have reported improved …

Brainstem blood brain barrier disruption using focused ultrasound: A demonstration of feasibility and enhanced doxorubicin delivery

S Alli, CA Figueiredo, B Golbourn, N Sabha… - Journal of controlled …, 2018 - Elsevier
Magnetic Resonance Image-guided Focused Ultrasound (MRgFUS) has been used to achieve
transient blood brain barrier (BBB) opening without tissue injury. Delivery of a targeted …

[HTML][HTML] PIK3C2B inhibition improves function and prolongs survival in myotubular myopathy animal models

N Sabha, JR Volpatti, H Gonorazky… - The Journal of …, 2016 - Am Soc Clin Investig
Myotubular myopathy (MTM) is a devastating pediatric neuromuscular disorder of phosphoinositide
(PIP) metabolism resulting from mutations of the PIP phosphatase MTM1 for which …

[HTML][HTML] Uropathogenic E. coli infection provokes epigenetic downregulation of CDKN2A (p16INK4A) in uroepithelial cells

C Tolg, N Sabha, R Cortese, T Panchal, A Ahsan… - Laboratory …, 2011 - Elsevier
Host cell and bacterial factors determine severity and duration of infections. To allow for
bacteria pathogenicity and persistence, bacteria have developed mechanisms that modify …

ATM regulates 3-methylpurine-DNA glycosylase and promotes therapeutic resistance to alkylating agents

…, S Pajovic, C Ternamian, R Head, N Sabha… - Cancer discovery, 2014 - AACR
Alkylating agents are a first-line therapy for the treatment of several aggressive cancers,
including pediatric glioblastoma, a lethal tumor in children. Unfortunately, many tumors are …

Analysis of IDH mutation, 1p/19q deletion, and PTEN loss delineates prognosis in clinical low-grade diffuse gliomas

N Sabha, CB Knobbe, M Maganti, S Al Omar… - Neuro …, 2014 - academic.oup.com
Background Grades II and III gliomas have unpredictable rates of progression, making
management decisions difficult. Currently, several clinical and radiological characteristics are …

MRI-guided focused ultrasound enhances drug delivery in experimental diffuse intrinsic pontine glioma

J Ishida, S Alli, A Bondoc, B Golbourn, N Sabha… - Journal of controlled …, 2021 - Elsevier
Diffuse intrinsic pontine glioma (DIPG) is a surgically unresectable and devasting tumour in
children. To date, there are no effective chemotherapeutics despite a myriad of clinical trials. …

High-grade glioma formation results from postnatal pten loss or mutant epidermal growth factor receptor expression in a transgenic mouse glioma model

…, L Clarke, DK Scheidenhelm, B Qian, A Tong, N Sabha… - Cancer research, 2006 - AACR
High-grade gliomas are devastating brain tumors associated with a mean survival of <50
weeks. Two of the most common genetic changes observed in these tumors are overexpression…