The post-translational modification (PTM) of proteins plays a critical role in the regulation of
a broad range of cellular processes in eukaryotes. Yet their role in governing similar systems …

Proteases enzymatically hydrolyze peptide bonds in substrate proteins, resulting in a
widespread, irreversible posttranslational modification of the protein’s structure and biological …

A combined glycomics and glycoproteomics strategy was developed for the site-specific
analysis of N-linked glycosylation heterogeneity from a complex mammalian protein mixture. …

To improve proteome coverage and protein C-terminal identification, we characterized the
Methanosarcina acetivorans thermophilic proteinase LysargiNase, which cleaves before …

Proteolytic treatment of intact bacterial cells is an ideal means for identifying surface‐exposed
peptide epitopes and has potential for the discovery of novel vaccine targets. Cell stability …

Enteroviruses encode proteinases that are essential for processing of the translated viral
polyprotein. In addition, viral proteinases also target host proteins to manipulate cellular …

The main viral protease (3CL pro ) is indispensable for SARS-CoV-2 replication. We
delineate the human protein substrate landscape of 3CL pro by TAILS substrate-targeted N-…

Controlled macrophage differentiation and activation in the initiation and resolution of
inflammation is crucial for averting progression to chronic inflammatory and autoimmune diseases. …

In healthy skin, epidermis and dermis are anchored together at the dermal-epidermal junction
(DEJ), a specialized basement membrane pivotal for skin integrity and function. However, …

The spatiotemporal proteome of the intervertebral disc (IVD) underpins its integrity and function.
We present DIPPER, a deep and comprehensive IVD proteomic resource comprising 94 …