T-bet is a STAT1-induced regulator of IL-12R expression in naïve CD4+ T cells
T helper type 1 (T H 1) cell development involves interferon-γ (IFN-γ) signaling through
signal transducer and activator of transcription 1 (STAT1) and interleukin-12 (IL-12) signaling …
signal transducer and activator of transcription 1 (STAT1) and interleukin-12 (IL-12) signaling …
Control of Effector CD8+ T Cell Function by the Transcription Factor Eomesodermin
Activated CD8 + T cells play a critical role in host defense against viruses, intracellular
microbes, and tumors. It is not clear if a key regulatory transcription factor unites the effector …
microbes, and tumors. It is not clear if a key regulatory transcription factor unites the effector …
Role of T-bet in Commitment of TH1 Cells Before IL-12-Dependent Selection
…, AV Villarino, DM Livingston, AL Kung, N Cereb… - Science, 2001 - science.org
How cytokines control differentiation of helper T (T H ) cells is controversial. We show that T-bet,
without apparent assistance from interleukin 12 (IL-12)/STAT4, specifies T H 1 effector …
without apparent assistance from interleukin 12 (IL-12)/STAT4, specifies T H 1 effector …
[HTML][HTML] HLA Diversity in the 1000 Genomes Dataset
PA Gourraud, P Khankhanian, N Cereb, SY Yang… - PloS one, 2014 - journals.plos.org
The 1000 Genomes Project aims to provide a deep characterization of human genome
sequence variation by sequencing at a level that should allow the genome-wide detection of …
sequence variation by sequencing at a level that should allow the genome-wide detection of …
Estimation of high-resolution HLA-A,-B,-C,-DRB1 allele and haplotype frequencies based on 8862 German stem cell donors and implications for strategic donor …
AH Schmidt, D Baier, UV Solloch, A Stahr, N Cereb… - Human immunology, 2009 - Elsevier
Human leukocyte antigen (HLA) haplotype frequency distributions in specific populations
can be applied to optimize both individual stem cell donor searches and donor registry …
can be applied to optimize both individual stem cell donor searches and donor registry …
[HTML][HTML] Distinguishing functional polymorphism from random variation in the sequences of >10,000 HLA-A, -B and -C alleles
J Robinson, LA Guethlein, N Cereb, SY Yang… - PLoS …, 2017 - journals.plos.org
HLA class I glycoproteins contain the functional sites that bind peptide antigens and engage
lymphocyte receptors. Recently, clinical application of sequence-based HLA typing has …
lymphocyte receptors. Recently, clinical application of sequence-based HLA typing has …
Common, intermediate and well‐documented HLA alleles in world populations: CIWD version 3.0. 0
…, R Freudenberger, A Manolis, J Mavrommatis, N Cereb… - Hla, 2020 - Wiley Online Library
A catalog of common, intermediate and well‐documented (CIWD) HLA‐A, ‐B, ‐C, ‐DRB1, ‐DRB3,
‐DRB4, ‐DRB5, ‐DQB1 and ‐DPB1 alleles has been compiled from over 8 million …
‐DRB4, ‐DRB5, ‐DQB1 and ‐DPB1 alleles has been compiled from over 8 million …
[HTML][HTML] High-accuracy HLA type inference from whole-genome sequencing data using population reference graphs
…, PA Gourraud, AJ Mentzer, N Cereb… - PLoS computational …, 2016 - journals.plos.org
Genetic variation at the Human Leucocyte Antigen (HLA) genes is associated with many
autoimmune and infectious disease phenotypes, is an important element of the immunological …
autoimmune and infectious disease phenotypes, is an important element of the immunological …
Advances in DNA sequencing technologies for high resolution HLA typing
N Cereb, HR Kim, J Ryu, SY Yang - Human immunology, 2015 - Elsevier
This communication describes our experience in large-scale G group-level high resolution
HLA typing using three different DNA sequencing platforms – ABI 3730 xl, Illumina MiSeq and …
HLA typing using three different DNA sequencing platforms – ABI 3730 xl, Illumina MiSeq and …
HLA* LA—HLA typing from linearly projected graph alignments
HLA*LA implements a new graph alignment model for human leukocyte antigen (HLA) type
inference, based on the projection of linear alignments onto a variation graph. It enables …
inference, based on the projection of linear alignments onto a variation graph. It enables …