Developmental signaling pathways control a vast array of biological processes during
embryogenesis and in adult life. The WNT pathway was discovered simultaneously in cancer and …

β-Amyloid (Aβ)-induced toxicity and oxidative stress have been postulated to play critical
roles in the pathogenic mechanism of Alzheimer disease (AD). We investigated the in vivo …

The nematode worm Caenorhabditis elegans (C. elegans) is increasingly popular as a
model organism for aging studies as well as for testing antioxidants and other compounds for …

The coronavirus responsible for the severe acute respiratory syndrome (SARS‐CoV) contains
a small envelope protein, E, with putative involvement in host cell apoptosis and virus …

Aims: To investigate the role of endogenous hydrogen sulfide (H 2 S) in the control of aging
and healthspan of Caenorhabditis elegans. Results: We show that the model organism, C. …

Alzheimer Disease (AD) is a progressive neurological disorder characterized by the
deposition of amyloid beta (Aβ), predominantly the Aβ 1–42 form, in the brain. Mitochondrial …

There is growing interest in pharmacological interventions directly targeting the aging process.
Pharmacological interventions against aging should be efficacious when started in adults …

Antioxidants are often investigated as a promising strategy for extending lifespan. Accordingly,
there is significant interest in novel antioxidant compounds derived from natural sources …

One of the most popular damage accumulation theories of ageing is the mitochondrial free
radical theory of ageing (mFRTA). The mFRTA proposes that ageing is due to the …

Coronaviruses contain a small envelope membrane protein with cation-selective ion
channel activity mediated by its transmembrane domain (ETM). In a computational study, we …