CRISPR-Cas9 nucleases are powerful genome engineering tools, but unwanted cleavage
at off-target and previously edited sites remains a major concern. Numerous strategies to …

CRISPR–Cas9 has yielded a plethora of effectors, including targeted transcriptional
activators, base editors and prime editors. Current approaches for inducibly modulating Cas9 …

Rationale: Despite contemporary therapy, coronary artery disease (CAD) remains a leading
cause of mortality. Genetic variants at ADAMTS7 have been associated with CAD and the …

Background The burden of blindness worldwide is unequal with regards to sex, with women
accounting for 64.5% of blindness. 1 While some of this discrepancy can be explained by …

Many future therapeutic applications of Clustered Regularly Interspaced Short Palindromic
Repeats (CRISPR)/Cas9 and related RNA-guided nucleases are likely to require their use to …

Loss-of-function mutations in the secreted enzyme ADAMTS7 (a disintegrin and metalloproteinase
with thrombospondin motifs 7) are associated with protection for coronary artery …

Age-related macular degeneration (AMD) is a leading cause of blindness in people over the
age of 55. Despite its common nature, the etiology of the disease involves both genetic and …

… Nicholas A. Popp and Dianke Yu contributed equally to this work and share first
authorship. … Popp and Dianke Yu contributed equally to this work and share first authorship. …

Purpose. To investigate how multipotent retinal stem cells (RSCs) isolated from mice
respond to the proinflammatory signaling molecules, IL-1β, IL-18, and IL-17A. Materials and …

This project further developed ultrasonic laboratory-scale equipment and established reliable
testing procedures to investigate the effect of water activity on the acoustic properties of …