Hereditary Early-Onset Parkinson's Disease Caused by Mutations in PINK1
Parkinson's disease (PD) is a neurodegenerative disorder characterized by degeneration of
dopaminergic neurons in the substantia nigra. We previously mapped a locus for a rare …
dopaminergic neurons in the substantia nigra. We previously mapped a locus for a rare …
Second consensus statement on the diagnosis of multiple system atrophy
Background: A consensus conference on multiple system atrophy (MSA) in 1998 established
criteria for diagnosis that have been accepted widely. Since then, clinical, laboratory, …
criteria for diagnosis that have been accepted widely. Since then, clinical, laboratory, …
Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease
We conducted a meta-analysis of Parkinson's disease genome-wide association studies
using a common set of 7,893,274 variants across 13,708 cases and 95,282 controls. Twenty-six …
using a common set of 7,893,274 variants across 13,708 cases and 95,282 controls. Twenty-six …
[HTML][HTML] Neurologic and developmental disability after extremely preterm birth
NS Wood, N Marlow, K Costeloe… - … England Journal of …, 2000 - Mass Medical Soc
Background Small studies show that many children born as extremely preterm infants have
neurologic and developmental disabilities. We evaluated all children who were born at 25 or …
neurologic and developmental disabilities. We evaluated all children who were born at 25 or …
[HTML][HTML] Association between Early-Onset Parkinson's Disease and Mutations in the Parkin Gene
…, G Meco, P Denèfle, NW Wood… - … England Journal of …, 2000 - Mass Medical Soc
Background Mutations in the parkin gene have recently been identified in patients with early-onset
Parkinson's disease, but the frequency of the mutations and the associated …
Parkinson's disease, but the frequency of the mutations and the associated …
[HTML][HTML] Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson's disease: a case-control study
Background Mutations in LRRK2, the gene that encodes leucine-rich repeat kinase 2, are a
cause of Parkinson's disease (PD). The International LRRK2 Consortium was established to …
cause of Parkinson's disease (PD). The International LRRK2 Consortium was established to …
Identification of novel risk loci, causal insights, and heritable risk for Parkinson's disease: a meta-analysis of genome-wide association studies
Background Genome-wide association studies (GWAS) in Parkinson's disease have increased
the scope of biological knowledge about the disease over the past decade. We aimed to …
the scope of biological knowledge about the disease over the past decade. We aimed to …
Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility
…, M Waller, P Weston, P Whittaker, S Widaa, NW Wood… - Nature …, 2011 - nature.com
Ankylosing spondylitis is a common form of inflammatory arthritis predominantly affecting
the spine and pelvis that occurs in approximately 5 out of 1,000 adults of European descent. …
the spine and pelvis that occurs in approximately 5 out of 1,000 adults of European descent. …
Expanding insights of mitochondrial dysfunction in Parkinson's disease
The quest to disentangle the aetiopathogenesis of Parkinson's disease has been heavily
influenced by the genes associated with the disease. The α-synuclein-centric theory of protein …
influenced by the genes associated with the disease. The α-synuclein-centric theory of protein …
A common LRRK2 mutation in idiopathic Parkinson's disease
Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene have been shown to cause
autosomal dominant Parkinson's disease. Few mutations in this gene have been identified. We …
autosomal dominant Parkinson's disease. Few mutations in this gene have been identified. We …