Feedback inhibition of gene expression is a widespread phenomenon in which the expression
of a gene is downregulated by its protein product. Feedback in eukaryotic cells involves …

In many developing tissues, adjacent cells diverge in character so as to create a fine-grained
pattern of cells in contrasting states of differentiation. It has been proposed that such …

Spontaneous pattern formation in reaction–diffusion systems on a spatially homogeneous
domain has been well studied. However, in embryonic development and elsewhere, pattern …

The Turing reaction–diffusion model [Phil. Trans. R. Soc. 237 (1952) 37–72] for self-organised
spatial pattern formation has been the subject of a great deal of study for the case of …

10.7554/eLife.42832.001 The existence of discrete phenotypic traits suggests that the complex
regulatory processes which produce them are functionally modular. These processes are …

Developmental signaling is remarkably robust to environmental variation, including temperature.
For example, in ectothermic animals such as Drosophila, Notch signaling is maintained …

10.7554/eLife.05789.001 To understand how long-range patterning gradients are interpreted
at the cellular level, we investigate how a gradient of expression of the Four-jointed kinase …

There are numerous examples of morphogen gradients controlling long range signalling in
developmental and cellular systems. The prospect of two such interacting morphogens …

Serum stimulation of a number of different mouse cell lines results in sustained oscillations
of Hes1, a member of this Hes/Her family of transcription factors. Quantitative time-course …

The leaf and root epidermis in Arabidopsis provide ideal systems in which to explore the
mechanisms that underlie the patterned assignment of cell fates during development. Extensive …