Purified plasma derived human albumin has been available as a therapeutic product since
World War II. However, cost effective recombinant production of albumin has been …

When 125 I-labeled blood platelets were lysed with an equal volume of 2% Triton X-100, 10
m/W EGTA, and 100 mM Tris, pH 7.4. the Triton-insoluble residue ("cytoskeleton") contained …

Both in vivo and in vitro, mice homozygous for the viable motheaten mutation show severe
immunodeficiency, polyclonal B-cell activation and Ig secretion, and spontaneous production …

Platelets deprived of calcium and incubated at 37 C for 10 min lose their ability to bind
fibrinogen or aggregate with ADP when adequate concentrations of calcium are restored. Since …

Therapeutic monoclonal antibodies (mAbs) represent one of the most important classes of
pharmaceutical proteins to treat human diseases. Most are produced in cultured mammalian …

Abstract 2730 CD20 is a cell-surface glycoprotein that is highly expressed on most B-cells,
tightly restricted to the B-cell lineage, and not expressed on either precursor lymphoid cells or …

Synonymous mutations, which do not alter the protein sequence, have been shown to affect
protein function [Sauna ZE, Kimchi-Sarfaty C (2011) Nat Rev Genet 12(10):683–691]. …

Most expression quantitative trait locus (eQTL) studies to date have been performed in
heterogeneous tissues as opposed to specific cell types. To better understand the cell-type–…

Both the low animal cell density of bioreactors and their ability to post-translationally process
recombinant factor IX (rFIX) limit hemophilia B therapy to <20% of the world’s population. …

Novel molecules that directly target the neonatal Fc receptor (FcRn) and/or Fc gamma
receptors (FcγRs) are emerging as promising treatments for immunoglobulin G (IgG)-dependent …