Amyotrophic lateral sclerosis (ALS) causes adult-onset, progressive motor neuron degeneration
in the brain and spinal cord, resulting in paralysis and death three to five years after …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease resulting in the
selective death of motor neurons in the brain and spinal cord 1 . Some familial cases of ALS are …

Background Parkinson's disease is typically treated with oral dopamine replacement therapies;
however, long-term treatment leads to motor complications and, occasionally, impulse …

In this report it is demonstrated for the first time that rabies-G envelope of the rabies virus is
sufficient to confer retrograde axonal transport to a heterologous virus/vector. After delivery of …

Parkinson's disease (PD) is a neurodegenerative disorder characterized by the selective
loss of dopaminergic neurons in the substantia nigra. This loss leads to complete dopamine …

We report a unique mutation in the D-amino acid oxidase gene (R199W DAO) associated
with classical adult onset familial amyotrophic lateral sclerosis (FALS) in a three generational …

Spinal muscular atrophy (SMA) is a frequent recessive autosomal disorder. It is caused by
mutations or deletion of the telomeric copy of the survival motor neuron (SMN) gene, leading …

In Parkinson’s disease, degeneration of specific neurons in the midbrain can cause severe
motor deficits, including tremors and the inability to initiate movement. The standard …

The management of disorders of the nervous system remains a medical challenge. The key
goals are to understand disease mechanisms, to validate therapeutic targets, and to develop …

Current therapies for Alzheimer’s disease (AD) are symptomatic and do not target the
underlying Aβ pathology and other important hallmarks including neuronal loss. PPARγ-coactivator…